475089-07-7

Basic information

• Product Name: 4-bromo-2-(methylthio)aniline
• Synonyms: 4-bromo-2-(methylthio)aniline
• CAS NO: 475089-07-7
• Molecular Weight: 218.117
• Mol File: 475089-07-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-bromo-2-(methylthio)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-(methylthio)aniline(475089-07-7)
• EPA Substance Registry System: 4-bromo-2-(methylthio)aniline(475089-07-7)

Safety Data

• Hazardous Substances Data: 475089-07-7(Hazardous Substances Data)

Upstream product

• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 15864-32-1 2-amino-6-bromobenzothiazole 
• 74-88-4 methyl iodide 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 1402436-86-5 6-bromo-2-phenylbenzo[b]thiophene 
• 1396554-49-6 4-bromo-2-(methylsulfonyl)aniline 
• 5304-21-2 6-bromo-2-methylbenzothiazole 

Relevant articles and documents

Visible Light-Induced Metal-Free and Oxidant-Free Radical Cyclization of (2-Isocyanoaryl)(methyl)sulfanes with Ethers

A novel cascade cyclization of (2-isocyanoaryl) (methyl)sulfanes and ethers is developed. With 4CzIPN as a photocatalyst and the irradiation of blue LED light, ether radicals are efficiently generated without adding any oxidant, endowing the strategy with features of oxidant-free, metal-free, mild reaction conditions, and operational simplicity. This strategy provides efficient approach to access various ether-containing benzothiazoles in acceptable to good yields.

Facile syntheses of 3-trifluoromethylthio substituted thioflavones and benzothiophenes via the radical cyclization

3-CF3S substituted thioflavones and benzothiophenes were achieved via the reactions of AgSCF3 with methylthiolated alkynones and alkynylthioanisoles, respectively, promoted by persulfate. This protocol possesses good functional group tolerance and high yields. Mechanistic studies suggested that a classic two-step radical process was involved, which includes addition of CF3S radical to triple bond and cyclization with SMe moiety.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.