475160-70-4Relevant articles and documents
Crown Ether Nucleophilic Catalysts (CENCs): Agents for Enhanced Silicon Radiofluorination
Jana, Susovan,Al-Huniti, Mohammed H.,Yang, Bo Yeun,Lu, Shuiyu,Pike, Victor W.,Lepore, Salvatore D.
, p. 2329 - 2335 (2017/03/11)
New bifunctional phase transfer agents were synthesized and investigated for their abilities to promote rapid fluorination at silicon. These agents, dubbed crown ether nucleophilic catalysts (CENCs), are 18-crown-6 derivatives containing a side-arm and a potentially nucleophilic hydroxyl group. These CENCs proved efficacious in the fluorination of hindered silicon substrates, with fluorination yields dependent on the length of linker connecting the metal chelating unit to the hydroxyl group. The efficacy of these CENCs was also demonstrated for rapid radiofluorination under mild conditions for eventual application in molecular imaging with positron emission tomography (PET). The hydrolysis-resistant aryl silicon fragment is promising as a convenient synthon for labeling potential PET radiotracers.
Introduction of 3-terminal nucleosides having a silyl-type linker into polymer supports without base protection
Ohkubo, Akihiro,Noma, Yasuhiro,Aoki, Katsufumi,Tsunoda, Hirosuke,Seio, Kohji,Sekine, Mitsuo
experimental part, p. 2817 - 2823 (2009/08/08)
New 3 -terminal deoxyribonucleoside-loading reagents having a silyl-type linker were developed. They were effectively introduced into polymer supports under the conditions of Huisgen [3 + 2] cycloaddition without base protection. Moreover, four unmodified
Silicon derivatives for PET imaging
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Page/Page column 15-16, (2010/11/30)
This invention relates to silicon-derivated compounds suitable for labelling or already labelled with 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of