475272-69-6

Basic information

• Product Name: 2-Pyridinecarboxylicacid,5-amino-6-(1-methylethoxy)-,methylester(9CI)
• Synonyms: 2-Pyridinecarboxylicacid,5-amino-6-(1-methylethoxy)-,methylester(9CI)
• CAS NO: 475272-69-6
• Molecular Formula: C₁₀H₁₄N₂O₃
• Molecular Weight: 0
• Product Categories: AMINOACID
• Mol File: 475272-69-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyridinecarboxylicacid,5-amino-6-(1-methylethoxy)-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylicacid,5-amino-6-(1-methylethoxy)-,methylester(9CI)(475272-69-6)
• EPA Substance Registry System: 2-Pyridinecarboxylicacid,5-amino-6-(1-methylethoxy)-,methylester(9CI)(475272-69-6)

Safety Data

• Hazardous Substances Data: 475272-69-6(Hazardous Substances Data)

Upstream product

• 186413-90-1 6-isopropoxy-5-nitropyridine-2-carboxylic acid 
• 186413-80-9 2-isopropoxy-3-nitro-6-vinylpyridine 
• 186413-77-4 6-chloro-3-nitro-2-(propan-2-yloxy)pyridine 
• 92138-35-7 6-chloro-3-nitro-1H-pyridin-2-one 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 475272-66-3 Methyl 6-isopropoxy-5-nitro-2-pyridinecarboxylate 

Downstream Products

• 475272-83-4 5-[(6-benzyloxy-5-nitro-pyridine-2-carbonyl)-amino]-6-isopropoxy-pyridine-2-carboxylic acid methyl ester 
• 1373319-36-8 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid 
• 1373319-48-2 methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate 
• 1373319-44-8 methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate 
• 475272-87-8 Methyl 5-{[(6-(benzyloxy)-5-{[(6-isopropoxy-5-nitro-2-pyridinyl)carbonyl]amino}-2-pyridinyl)carbonyl]amino}-6-isopropoxy-2-pyridine carboxylate 
• 475272-74-3 Methyl 5-{[(5-amino-6-(benzyloxy)-2-pyridinyl)carbonyl]amino}-6-isopropoxy-2-pyridinecarboxylate 

Relevant articles and documents

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: Identification of potent Bcl-xL inhibitors

By conducting a structure-activity relationship study of the backbone of a series of oligoamide-foldamer-based α-helix mimetics of the Bak BH3 helix, we have identified especially potent inhibitors of Bcl-xL. The most potent compound has a Ki value of 94 nM in vitro, and single-digit micromolar IC50 values against the proliferation of several Bcl-xL-overexpressing cancer cell lines. The Royal Society of Chemistry 2012.

Design and application of an α-helix-mimetic scaffold based on an oligoamide-foldamer strategy: Antagonism of the Bak BH3/Bcl-xL complex

The prevention of cell death by the antiapoptotic protein Bcl-xL has been linked to a number of cancers. Bcl-xl binds to the BH3 domain of the proapoptotic protein Bak, thus preventing programmed cell death. A competitive assay and docking studies have shown that the polyamide scaffold 1, which was synthesized based on a rational structure-based design, interferes with the Bak BH3/Bcl-xl complexation.