475479-34-6

Basic information

• Product Name: ALEGLITAZAR
• Synonyms: ALEGLITAZAR;(S)-2-Methoxy-3-[4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]benzo[b]thiophen-7-yl]propionic acid;Unii-41T4oag59u;Benzo[b]thiophene-7-propanoicacid, a-Methoxy-4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]-,(aS)-;R 1439;R1439;R-1439;RO 0728804
• CAS NO: 475479-34-6
• Molecular Formula: C₂₄H₂₃NO₅S
• Molecular Weight: 437.514
• Mol File: 475479-34-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 146-147 °C
• Boiling Point: 665.151 °C at 760 mmHg
• Flash Point: 356.071 °C
• Appearance: /
• Density: 1.290
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.627
• PKA: 3.54±0.46(Predicted)
• CAS DataBase Reference: ALEGLITAZAR(CAS DataBase Reference)
• NIST Chemistry Reference: ALEGLITAZAR(475479-34-6)
• EPA Substance Registry System: ALEGLITAZAR(475479-34-6)

Safety Data

• Hazardous Substances Data: 475479-34-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1

Upstream product

• 475479-24-4 2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid 
• 475480-89-8 (S)-4-benzyl-3-((S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionyl)-oxazolidin-2-one 
• 849150-55-6 (Z)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-acrylic acid 

Downstream Products

• 849150-56-7 (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid (S)-phenyl ethylamine salt 
• 1578246-97-5 diisopropylammonium (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propanoate 
• 881663-41-8 (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid L-norephedrine salt 

Relevant articles and documents

SOLID STATE FORMS OF ALEGLITAZAR SODIUM

The present invention provides solid state forms of Aleglitazar sodium, processes for preparing the solid state forms, and pharmaceutical compositions comprising the solid state forms.

PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES

The invention relates to a process for the preparation of a compound of formula (I) or a salt thereof.

Process for the production of chiral propionic acid derivatives

The present invention is concerned with a novel process for the preparation of compounds of formula I comprising catalytic asymmetric hydrogenation of a compound of formula (II) in the presence of a catalyst comprising ruthenium and a chiral diphosphine ligand or comprising rhodium and a chiral diphosphine ligand, wherein R1, R2, R3 and R4 are as defined in the specification and claims. The compounds of formula I and the corresponding salts and/or esters are pharmaceutically active substances.