4755-50-4

Basic information

• Product Name: 4-DIMETHYLAMINOBENZOYL CHLORIDE
• Synonyms: 4-DIMETHYLAMINOBENZOYL CHLORIDE;4-(Dimethylamino)benzoic acid chloride;p-(Dimethylamino)benzoyl chloride;4-(Dimethylamino)benzoyl chloride,97%;4-(Dimethylamino)benzoyl chloride, 95%, 95%;[4-(diMethylaMino)phenyl]carbonylchloranuide;Benzoyl chloride,4-(diMethylaMino)-;4-(Chlorocarbonyl)-N,N-dimethylaniline, 4-(Chloroformyl)-N,N-dimethylaniline
• CAS NO: 4755-50-4
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.63
• Product Categories: Carbonyl Chlorides;Phenyls & Phenyl-Het;Carbonyl Chlorides;Phenyls & Phenyl-Het;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 4755-50-4.mol
• Article Data: 75

Chemical Properties

• Melting Point: 145-149 °C(lit.)
• Boiling Point: 180℃ (15 Torr)
• Flash Point: 122.5 °C
• Appearance: White to tan crystalline powder
• Density: 1.193 g/cm³
• Vapor Pressure: 0.00412mmHg at 25°C
• Refractive Index: 1.574
• PKA: 0.98±0.12(Predicted)
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• BRN: 1100858
• CAS DataBase Reference: 4-DIMETHYLAMINOBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIMETHYLAMINOBENZOYL CHLORIDE(4755-50-4)
• EPA Substance Registry System: 4-DIMETHYLAMINOBENZOYL CHLORIDE(4755-50-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 4755-50-4(Hazardous Substances Data)

Usage

Chemical Properties

White to tan crystalline powder

Uses

4-Dimethylaminobenzoyl chloride is used to make other chemicals. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

General Description

4-(Dimethylamino)benzoyl chloride is also referred to as 4-(chloroformyl)-N,N-dimethylaniline.

InChI:InChI=1/C9H10ClNO/c1-11(2)8-5-3-7(4-6-8)9(10)12/h3-6H,1-2H3

Upstream product

• 619-84-1 p-N,N-dimethylaminobenzoic acid 
• 157119-18-1 (4-dimethylamino-phenyl)-oxoacetyl chloride 
• 698-70-4 4-Iodo-N,N-dimethylaniline 
• 141-75-3 butyryl chloride 
• 121-69-7 N,N-dimethyl-aniline 
• 150-13-0 4-amino-benzoic acid 
• 89165-28-6 1-(p-dimethylamino)benzoyl-3-methylimidazolium chloride 
• 79-37-8 oxalyl dichloride 
• 75-44-5 phosgene 

Downstream Products

• 1230-64-4 4-(dimethylamino)-N-(4-(dimethylamino)phenyl)benzamide 
• 21566-11-0 N,N-dimethyl-p-(dimethylamino)benzamide 
• 55198-74-8 4-dimethylamino-2'-methylbenzanilide 
• 20934-81-0 4-(benzo[d]oxazol-2-yl)aniline 
• 4870-76-2 2-{4-(dimethylamino)phenyl}-3-methylbenzothiazolium iodide 
• 20144-01-8 2-(4-dimethylamino-phenyl)-3-ethyl-benzothiazolium; iodide 
• 21223-76-7 3-benzyl-2-(4-dimethylamino-phenyl)-benzothiazolium; chloride 
• 81620-87-3 N-(4-pyridyl)methyl-N',N'-dimethylaminobenzamide 
• 148122-89-8 7-p-dimethylaminobenzoyl-8-dimethylaminotheophylline 
• 22636-68-6 allyl 4-(dimethylamino)benzoate 
• 467-63-0 crystal violet carbinol base 
• 7647-01-0 hydrogenchloride 

Relevant articles and documents

Synthesis and activity of four (N,N-dimethylamino)benzamide non-steroidal anti-inflammatory drugs based on thiazole and thiazoline

Four compounds derived from 2-aminothiazole and 2-amino-2-thiazoline were prepared by coupling the respective bases with the acid chlorides of either 3- or 4-(N,N-dimethylamino)benzoic acid. Products were identified using infrared spectroscopy. 1/su

Ni-Catalyzed Direct Carboxylation of Aryl C?H Bonds in Benzamides with CO2

The direct carboxylation of inert aryl C?H bond catalyzed by abundant and cheap nickel is still facing challenge. Herein, we report the Ni-catalyzed direct carboxylation of aryl C?H bonds in benzamides under 1 atm of CO2 to afford various methyl carboxylates or phthalimides, dealing with different post-processing. The reaction displays excellent functional group tolerance and affords moderate to high carboxylation yields under mild conditions. Detail mechanistic studies suggest that a Ni(0)?Ni(II)?Ni(I) catalytic cycle may be involved in this reaction. (Figure presented.).

Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes

The difluoromethyl (CHF2) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocat

AMINE CO-INITIATOR MIXTURE

The invention relates to a co-initiator comprising the aminobenzoate derivative according to Formula (I) and at least one ancillary amine, wherein the reactivity and solubility of said co-imitator in UV-curable resins is sufficiently high that the co-initiator can be used in UV radiation curing processes. Formula (I) wherein R1 and R2 independently represent methyl or ethyl groups; and j, k, l and m are independently 0 to 20.