476013-32-8

Basic information

• Product Name: (2'S,3'S,5S,6R)-3,4,5,6-tetrahydro-3-(3'-hydroxy-2'-methyl-3'-phenyl-propionyl)-4,5-dimethyl-6-phenyl-2H-1,3,4-oxadiazin-2-one
• Synonyms: (2'S,3'S,5S,6R)-3,4,5,6-tetrahydro-3-(3'-hydroxy-2'-methyl-3'-phenyl-propionyl)-4,5-dimethyl-6-phenyl-2H-1,3,4-oxadiazin-2-one
• CAS NO: 476013-32-8
• Molecular Weight: 368.433
• Mol File: 476013-32-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2'S,3'S,5S,6R)-3,4,5,6-tetrahydro-3-(3'-hydroxy-2'-methyl-3'-phenyl-propionyl)-4,5-dimethyl-6-phenyl-2H-1,3,4-oxadiazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2'S,3'S,5S,6R)-3,4,5,6-tetrahydro-3-(3'-hydroxy-2'-methyl-3'-phenyl-propionyl)-4,5-dimethyl-6-phenyl-2H-1,3,4-oxadiazin-2-one(476013-32-8)
• EPA Substance Registry System: (2'S,3'S,5S,6R)-3,4,5,6-tetrahydro-3-(3'-hydroxy-2'-methyl-3'-phenyl-propionyl)-4,5-dimethyl-6-phenyl-2H-1,3,4-oxadiazin-2-one(476013-32-8)

Safety Data

• Hazardous Substances Data: 476013-32-8(Hazardous Substances Data)

Upstream product

• 397332-61-5 (5S,6R)-4,5-dimethyl-6-phenyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one 
• 1850-61-9 (1R,2S)-N-methyl-N-nitroso-2-amino-1-phenyl-1-propanol 
• 67462-20-8 (1R,2S)-N-amino-2-methylamino-1-phenyl-1-propanol 
• 299-42-3 ephedrine 
• 100-52-7 benzaldehyde 
• 397332-07-9 (5S,6R)-4,5-dimethyl-6-phenyl-3-propionyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one 

Downstream Products

• 76549-02-5 (-)-(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoic acid 
• 397332-61-5 (5S,6R)-4,5-dimethyl-6-phenyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one 

Relevant articles and documents

An improved procedure for the asymmetric aldol reaction of the titanium enolate of an N3-propionyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one

The direct formation of the titanium enolate of N3-propionyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one has been achieved through complexation with titanium tetrachloride at 25°C, followed by deprotonation with triethylamine (-78 to 25°C). The preformed titanium enolate has been reacted with D2O/DCl to afford deuterated derivative 6 and also reacted with a series of aromatic and aliphatic aldehydes affording aldol adducts 4a-f with crude diastereoselectivities ranging from 8:1 to 38:1.