476199-14-1

Basic information

• Product Name: 4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
• Synonyms: 4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID;4-Methoxy-1-benzothiophene-2-carboxylic acid;4-Methoxybenzothiophene-2-carboxylic acid;Benzo[b]thiophene-2-carboxylic acid, 4-methoxy-
• CAS NO: 476199-14-1
• Molecular Formula: C10H8O3S
• Molecular Weight: 208.23
• EINECS: 200-589-5
• Mol File: 476199-14-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 410 °C at 760 mmHg
• Flash Point: 201.761 °C
• Appearance: /
• Density: 1.392 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.673
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID(476199-14-1)
• EPA Substance Registry System: 4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID(476199-14-1)

Safety Data

• Hazardous Substances Data: 476199-14-1(Hazardous Substances Data)

Usage

General Description

4-Methoxy-benzo[b]thiophene-2-carboxylic acid is a chemical compound with a molecular formula C11H8O3S. It is a derivative of benzo[b]thiophene and contains a carboxylic acid group. 4-Methoxy-benzo[b]thiophene-2-carboxylic acid is often used in organic synthesis and medicinal chemistry as a building block for the preparation of various drug candidates and biologically active molecules. The methoxy group on the benzene ring and the carboxylic acid functionality make it a versatile starting material for the synthesis of diverse chemical compounds. Its unique molecular structure offers potential for developing novel pharmaceuticals and materials.

InChI:InChI=1/C10H8O3S/c1-13-7-3-2-4-8-6(7)5-9(14-8)10(11)12/h2-5H,1H3,(H,11,12)

Upstream product

• 146137-74-8 2-fluoro-6-methoxybenzaldehyde 
• 146137-88-4 methyl 4-methoxybenzo[b]thiophene-2-carboxylate 

Downstream Products

• 476199-13-0 4-methoxy-1-benzothiophene-2-carbonitrile 
• 476199-30-1 2-cyano-4-hydroxybenzothiophene 

Relevant articles and documents

Design, synthesis, and biological evaluation of benzo[b]thiophene 1,1-dioxide derivatives as potent STAT3 inhibitors

As a member of the signal transducer and activator of transcription (STAT) family, STAT3 plays a critical role in several biological pathways such as cell proliferation, migration, survival, and differentiation. Due to abnormal continuous activation in tumors, inhibition of STAT3 has emerged as an attractive approach for the treatment of various cancer cells. Herein, we report a series of novel STAT3 inhibitors based on benzo[b]thiophene 1,1-dioxide scaffold and evaluated their anticancer potency. Among them, compound 8b exhibited the best activity against cancer cells. Compound 8b induced apoptosis and blocked the cell cycle. Meanwhile, 8b reduced intracellular ROS content and caused the loss of mitochondrial membrane potential. Further research revealed that 8b significantly blocked STAT3 phosphorylation and STAT3-dependent dual-luciferase reporter gene experiments showed that compound 8b has a marked inhibition of STAT3-mediated Firefly luciferase activity. Molecular modeling studies revealed compound 8b occupied the pocket well with the SH2 domain in a favorable conformation.

METHOD FOR PROMOTING PLANT GROWTH

The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound selected from a group consisting of a compound represented by the following Formula (1): and an agriculturally acceptable salt thereof, provided that a method for promoting plant growth which comprises treating plants with a compound corresponding to any one of the following (1) to (5) and an agriculturally acceptable salt thereof is excluded: (1) 4-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (2) 5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (3) 6-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (4) 7-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, and (5) Benzo[b]thiophene-2-carboxylic acid.