476296-68-1Relevant articles and documents
Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase
Ding, Yili,Smith, Kenneth L.,Varaprasad, Chamakura V.N.S.,Chang, Eugene,Alexander, John,Yao, Nanhua
, p. 841 - 845 (2007/10/03)
Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 nM of IC50 inhibitory activity.