476374-04-6

Basic information

• Product Name: [4-(6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetic acid ethyl ester
• Synonyms: [4-(6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetic acid ethyl ester
• CAS NO: 476374-04-6
• Molecular Weight: 343.333
• Mol File: 476374-04-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetic acid ethyl ester(476374-04-6)
• EPA Substance Registry System: [4-(6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetic acid ethyl ester(476374-04-6)

Safety Data

• Hazardous Substances Data: 476374-04-6(Hazardous Substances Data)

Upstream product

• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 143007-15-2 2-chloro-6,7-difluoroquinoxaline 

Downstream Products

• 476374-09-1 [4-(6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetic acid 
• 476374-15-9 (S)-2-{2-[4-(6,7-Difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester 

Relevant articles and documents

Quinoxaline chemistry. Part 14. 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-L-glutamates as analogues-homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity

Among a new series of 26 4-(3-substituted-2-quinoxalylamino)phenylacetates and 4-(3-substituted-2-quinoxalylamino)-phenylacetyl-L-glutamates, eight were selected at NCI for evaluation of their in vitro anticancer activity. The results obtained in comparison with the corresponding nor-compounds series seem to indicate that this type of homologation is not helpful.