4765-36-0

Basic information

• Product Name: 1-(2-methylphenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
• CAS NO: 4765-36-0
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 227.2188
• Mol File: 4765-36-0.mol
• Article Data: 3

Chemical Properties

• Density: 1.37g/cm³
• Refractive Index: 1.646
• CAS DataBase Reference: 1-(2-methylphenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methylphenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile(4765-36-0)
• EPA Substance Registry System: 1-(2-methylphenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile(4765-36-0)

Safety Data

• Hazardous Substances Data: 4765-36-0(Hazardous Substances Data)

Upstream product

• 16620-52-3 5-methoxygramine 
• 4771-67-9 5-methoxy-3-(2,2-dimethyl-2-nitroethyl)-1H-indole 

Downstream Products

• 72742-84-8 2-[2-hydroxy-3-[[2-(5-methoxy-1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile hydrochloride 
• 77216-32-1 2-[2-hydroxy-3-[[2-(5-methoxy-1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile 
• 77216-23-0 1-[[2-(5-methoxy-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol 

Relevant articles and documents

ORGANIC COMPOUNDS

The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.

3-INDOLYL-TERTIARY BUTYLAMINOPROPANOLS

1-Phenoxy-3-(3-indolyl)-tert.-butyl!amino-2-propanols and related 1-aryloxy compounds are antihypertensive agents having vasodilator and adrenergic β-receptor blocking action. Preferred compounds bear an ortho-substituent in the phenoxy group, and most preferably the cyano group.