4765-50-8

Basic information

• Product Name: 4(1H)-Quinazolinone, 2-(2-chlorophenyl)-
• CAS NO: 4765-50-8
• Molecular Formula: C14H9ClN2O
• Molecular Weight: 256.691
• Mol File: 4765-50-8.mol
• Article Data: 63

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinazolinone, 2-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinazolinone, 2-(2-chlorophenyl)-(4765-50-8)
• EPA Substance Registry System: 4(1H)-Quinazolinone, 2-(2-chlorophenyl)-(4765-50-8)

Safety Data

• Hazardous Substances Data: 4765-50-8(Hazardous Substances Data)

Upstream product

• 4765-49-5 N-(2-chloro-benzoyl)-anthranilic acid amide 
• 118-48-9 isatoic anhydride 
• 89-98-5 2-chloro-benzaldehyde 
• 2136-89-2 2-chlorobenzotrichloride 
• 28144-70-9 anthranilic acid amide 
• 873-32-5 2-Chlorobenzonitrile 
• 610-15-1 2-nitrobenzamide 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 1885-29-6 anthranilic acid nitrile 
• 26118-14-9 o-chlorobenzoylformic acid 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 117507-62-7 2-amino-N-[(2-chlorophenyl)methyl]benzamide 
• 118-92-3 anthranilic acid 
• 4765-51-9 2-(2-chlorophenyl)benzo[d]1,3-oxazin-4-one 

Downstream Products

• 59455-92-4 4-chloro-2-(2-chloro-phenyl)-quinazoline 
• 18590-76-6 2-(2-chlorophenyl)-4(3H)-quinazolinethione 
• 332850-65-4 C₁₄H₁₁ClN₄ 
• 1448068-42-5 C₁₅H₁₀ClN₅ 

Relevant articles and documents

Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones fromo-nitrobenzamide and alcohols

Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily availableo-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including

Electrochemically induced synthesis of quinazolinonesviacathode hydration ofo-aminobenzonitriles in aqueous solutions

An efficient and practical electrochemically catalyzed transition metal-free process for the synthesis of substituted quinazolinones from simple and readily availableo-aminobenzonitriles and aldehydes in water has been accomplished. I2/base and water play an unprecedented and vital role in the reaction. By electrochemically catalysed hydrolysis ofo-aminobenzonitriles, the synthesis of quinazolinones with benzaldehyde was first proposed. The synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactiveN-(2,5-dichlorophenyl)-6-(2,2,2-trifluoroethoxy) pteridin-4-amine, which enables straightforward, practical and environmentally benign quinazolinone formation.

Electro-oxidative cyclization: Access to quinazolinones: Via K2S2O8without transition metal catalyst and base

A K2S2O8-promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base. The key feature of this protocol is the utilization of K2S2O8 as an inexpensive and easy-to-handle radical surrogate that can effectively promote the reaction via a simple procedure, leading to the formation of nitrogen heterocycles via direct oxidative cyclization at room temperature in a one-pot procedure under constant current. Owing to the use of continuous-flow electrochemical setups, this green, mild and practical electrosynthesis features high efficiency and excellent functional group tolerance and is easy to scale up.