4765-57-5

Basic information

• Product Name: 2-(2-phenylethyl)quinazolin-4(1H)-one
• CAS NO: 4765-57-5
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.2952
• Mol File: 4765-57-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 436.2°C at 760 mmHg
• Flash Point: 217.6°C
• Density: 1.18g/cm³
• Vapor Pressure: 8.21E-08mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 2-(2-phenylethyl)quinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylethyl)quinazolin-4(1H)-one(4765-57-5)
• EPA Substance Registry System: 2-(2-phenylethyl)quinazolin-4(1H)-one(4765-57-5)

Safety Data

• Hazardous Substances Data: 4765-57-5(Hazardous Substances Data)

Usage

Chemical class

Quinazolinone

Derivative

2-(2-phenylethyl)quinazolin-4(1H)-one is a derivative of quinazoline.

Also known as

Phensuximide

Pharmaceutical applications

The compound has been investigated for its potential use in the treatment of epilepsy, Parkinson's disease, and neuropathic pain.

Anticonvulsant properties

2-(2-phenylethyl)quinazolin-4(1H)-one has demonstrated anticonvulsant properties in animal studies.

Research use

The compound has been used as a reference compound in research on antiepileptic drugs.

Chemical structure

The chemical structure of 2-(2-phenylethyl)quinazolin-4(1H)-one makes it an interesting target for further research in the field of neuroscience and drug development.

Upstream product

• 53905-19-4 (E)-2-styrylquinazolin-4(3H)-one 
• 142005-11-6 2-(3-phenyl-propionylamino)benzoic acid 
• 108-24-7 acetic anhydride 
• 313382-30-8 2-(3-phenyl-propionylamino)-benzamide 
• 28144-70-9 anthranilic acid amide 
• 501-52-0 3-Phenylpropionic acid 
• 118-92-3 anthranilic acid 
• 645-45-4 hydrocinnamic acid chloride 
• 645-59-0 dihydrocinnamonitrile 
• 122-97-4 3-Phenyl-1-propanol 
• 104-53-0 3-phenyl-propionaldehyde 
• 118-48-9 isatoic anhydride 
• 80478-02-0 2-phenethyl-1,2,3,4-tetrahydroquinazolin-4-one 
• 100-42-5 styrene 

Downstream Products

• 1233224-93-5 C₂₄H₁₉N₅O₃ 

Relevant articles and documents

Metal-free catalyst for the visible-light-induced photocatalytic synthesis of quinazolinones

In the present work, we have developed a novel and environmentally friendly method for the synthesis of quinazolinones using fluorescein as a photocatalyst via a condensation reaction of o-aminobenzamides and aldehydes under visible light irradiation. In this protocol, neither toxic oxidants nor transition-metal catalysts were needed, and a series of quinazolinones could be obtained in high efficiencies. In addition, this reaction can be extended to gram levels and has a large potential of wide application in future industrialization.

Method for preparing quinazolinone from enol

The invention discloses a method for preparing a quinazolinone derivative from enol. According to the method, a relatively inexpensive ruthenium complex is used as a catalyst in a reaction to catalyzea microwave reaction of commercial and easily-available 2-aminobenzamide with enol for the preparation of quinazolinone. Compared with conventional synthesis methods for quinazolinone of the same kind, the method of the invention has the following advantages: no alkali is used in the reaction process; clean and non-toxic tetrahydrofuran is used as a reaction solvent; hydrogen is automatically transferred, and the atom economy of the reaction is high; and the by-product of the invention is only water.

The Synthesis of Quinazolinones from Olefins, CO, and Amines over a Heterogeneous Ru-clusters/Ceria Catalyst

Quinazolinones, an important class of heterocyclic compounds, have been widely used in pharmaceuticals because of their biological activity. However, the efficient and economical synthesis of quinazolinones has remained a challenge. A novel synthetic approach has now been developed to produce quinazolinones from olefins, CO, and amines over heterogeneous Ru-clusters/ceria catalyst in the absence of acids, bases, and oxidants. Furthermore, H2O is generated as the only by-product. A series of quinazolinones with aromatic or non-aromatic substituents can be obtained in yields of up to 99 %. The Ru-clusters/ceria can be reused at least four times. The analysis of the E-factor (environmental impact factor) for the synthesis of 2-ethyl quinazolinone suggests that this system is more environmentally friendly than other processes reported previously.