4765-71-3Relevant articles and documents
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4] triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity
Guertin, Kevin R.,Setti, Lina,Qi, Lida,Dunsdon, Rachel M.,Dymock, Brian W.,Jones, Philip S.,Overton, Hilary,Taylor, Mathew,Williams, Glyn,Sergi, Joseph A.,Wang, Karen,Peng, Ying,Renzetti, Marcia,Boyce, Rogely,Falcioni, Fiorenza,Garippa, Ralph,Olivier, Andree R.
, p. 2895 - 2898 (2003)
A novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine- based hypoglycemic agents have been identified. These compounds show non-selective inhibitory properties against a panel of protein tyrosine phosphatases including PTP1B. Compounds 12 and 13 display oral glucose lowering effects in ob/ob mice.
