4771-49-7

Basic information

• Product Name: 6-METHYLINDOLE-3-CARBOXALDEHYDE
• Synonyms: 6-METHYLINDOLE-3-ALDEHYDE;6-METHYLINDOLE-3-CARBOXALDEHYDE;6-METHYLINDOLE-3-CARBOXYALDEHYDE;6-METHYL-1H-INDOLE-3-CARBALDEHYDE;AKOS JY2083588;3-Formyl-6-methylindole;6-Methylindole-3-caboxaldehyde;6-Methylindole-3-carboxaldehyde,98%
• CAS NO: 4771-49-7
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Product Categories: ALDEHYDE;Indoles and derivatives;Indole
• Mol File: 4771-49-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 185-189°C
• Boiling Point: 339.3ºC at 760 mmHg
• Flash Point: 167ºC
• Appearance: /
• Density: 1.226g/cm3
• Vapor Pressure: 9.27E-05mmHg at 25°C
• Refractive Index: 1.698
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 15.86±0.30(Predicted)
• Sensitive: Air Sensitive
• BRN: 386914
• CAS DataBase Reference: 6-METHYLINDOLE-3-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYLINDOLE-3-CARBOXALDEHYDE(4771-49-7)
• EPA Substance Registry System: 6-METHYLINDOLE-3-CARBOXALDEHYDE(4771-49-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36
• Hazardous Substances Data: 4771-49-7(Hazardous Substances Data)

Usage

General Description

6-METHYLINDOLE-3-CARBOXALDEHYDE is a chemical compound with the molecular formula C10H9NO and a molecular weight of 159.18 g/mol. It is an aldehyde derivative of 6-methylindole, also known as 6-methyltryptophan, and is commonly used in the synthesis of pharmaceutical and agrochemical products. 6-METHYLINDOLE-3-CARBOXALDEHYDE has been studied for potential use in the development of drugs for the treatment of certain diseases, including cancer and neurological disorders. It is also used as a building block in the production of various organic compounds and as a raw material for the synthesis of other chemicals. Additionally, 6-METHYLINDOLE-3-CARBOXALDEHYDE has been investigated for its potential environmental and health impacts, but further research is needed to fully understand its properties and potential applications.

InChI:InChI=1/C10H9NO/c1-7-2-3-9-8(6-12)5-11-10(9)4-7/h2-6,11H,1H3

Upstream product

• 3420-02-8 6-methylindole 
• 50-00-0 formaldehyd 
• 100-97-0 hexamethylenetetramine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 191670-98-1 (E)-2-(3,4-Dihydroxybutyl)-3-(6-methylindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one 
• 243636-31-9 3-(6-Methylindol-3-yl)-2-[(2S),(3R)-2,3,4-trihydroxy-butylthio]-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one 
• 243636-32-0 3-(6-Methylindol-3-yl)-2-[(2R),(3S)-2,3,4-trihydroxy-butylthio]-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one 
• 202584-14-3 1,6-dimethyl-1H-indole-3-carbaldehyde 
• 914348-95-1 tert-butyl 6-methyl-3-formylindole-1-carboxylate 
• 934610-38-5 C₁₉H₁₆N₂O₂ 
• 934610-47-6 C₁₇H₁₂N₂O₂ 

Relevant articles and documents

Cu-Catalyzed Dimerization of Indole Derived Oxime Acetate for Synthesis of Biimidazo[1,2- a]indoles

A copper-mediated cyclization and dimerization of indole derived oxime acetate was developed to generate a series of biimidazo[1,2-a]indole scaffolds with two contiguous stereogenic quaternary carbons in one step.

Access to Polycyclic Thienoindolines via Formal [2+2+1] Cyclization of Alkynyl Indoles with S8and K2S

The syntheses of polycyclic thienoindolines bearing a dihydrothiophene or tetrahydrothiophene subunit have not been reported, despite the fact that such compounds may have interesting medicinal properties. Herein, we report a protocol for accessing polycyclic dihydrothiophenes by means of formal [2+2+1] intramolecular dearomatizing cyclization of alkynyl indoles with K2S and S8 as the sources of sulfide. In addition, tetrahydrothienoindolines were stereoselectively synthesized via a one-pot, two-step protocol involving AgNO3-catalyzed alkenyl dearomatization followed by two nucleophilic addition reactions involving K2S.

Potassium-ion competitive acid blocker containing indole structure and preparation method and application of potassium-ion competitive acid blocker

The invention discloses an indole derivative or a pharmaceutically acceptable salt thereof and particularly relates to a compound containing a 1-sulfonyl-3-alkylamino methyl indole structure. The compound is shown as a formula I. The invention also discloses a preparation method of the indole derivative and application of the indole derivative in preparation of a potassium-ion competitive acid blocker or a drug for treating acid-related diseases. The preparation method has the advantages of being simple and high in yield and reproducibility.