4771-50-0 Usage
Description
7-METHYLINDOLE-3-CARBOXALDEHYDE is an organic compound with the molecular formula C9H7NO. It is a derivative of indole and features a carboxylic aldehyde functional group. 7-METHYLINDOLE-3-CARBOXALDEHYDE is known for its potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
7-METHYLINDOLE-3-CARBOXALDEHYDE is used as a reactant for the preparation of various compounds with therapeutic potential. It serves as a building block for the synthesis of different pharmaceutical agents, including:
1. Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, which are potential anticancer immunomodulators. These compounds can modulate the immune system to enhance the body's response against cancer cells.
2. Antibacterial and antituberculosis agents. These agents can help in the treatment of bacterial infections, including tuberculosis, by targeting specific bacterial enzymes or pathways.
3. Antiandrogens effective against androgen receptor mutants. These compounds can be used in the treatment of prostate cancer and other androgen-dependent conditions by blocking the action of androgens on their receptors.
4. Anti-bovine viral diarrhea virus (BVDV) agents. These agents can help in the prevention and treatment of BVDV infections in cattle, which can lead to significant economic losses in the livestock industry.
5. Receptor subtype 5 antagonists. These compounds can be used in the treatment of various conditions, including neurological disorders, by blocking the action of specific receptors in the body.
6. Glucocorticoid receptor ligands. These compounds can modulate the activity of the glucocorticoid receptor, which plays a crucial role in the regulation of immune responses and stress responses.
7. Necroptosis inhibitors. These compounds can inhibit a form of programmed cell death called necroptosis, which is involved in various pathological conditions, including neurodegenerative diseases and ischemic injuries.
8. Orally efficacious small-molecule activator of the insulin receptor. These compounds can enhance the activity of the insulin receptor, which may be useful in the treatment of diabetes and other conditions related to insulin resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 4771-50-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,7 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4771-50:
(6*4)+(5*7)+(4*7)+(3*1)+(2*5)+(1*0)=100
100 % 10 = 0
So 4771-50-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO/c1-7-3-2-4-9-8(6-12)5-11-10(7)9/h2-6,11H,1H3
4771-50-0Relevant articles and documents
Access to Polycyclic Indol(en)ines via Base-Catalyzed Intramolecular Dearomatizing 3-Alkenylation of Alkynyl Indoles
Liu, Bo,Lu, Lin,Yang, Yongjie,Yin, Biaolin,Zheng, Zuoliang
, p. 2207 - 2212 (2021)
Polycyclic indolines and indolenines were synthesized via base-catalyzed intramolecular dearomatizing 3-alkenylation reactions of alkynyl indoles 1 at room temperature. The base enhanced the nucleophilicity of the carbon at the 3-position of the indole moiety, facilitating an exclusive 5-exo-dig cyclization reaction with the alkyne to form spiroindolenines 2. The imine functionality of 2 could undergo in situ nucleophilic addition to form spiroindolines 3 when R was a carbamoyl group or reduction to form spiroindolines 4 when R was H.
Preparation method of non-natural L - tryptophan derivative
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Paragraph 0030-0034; 0046-0048; 0059-0061; 0072-0074; ..., (2021/11/21)
The invention discloses a preparation method of a non-natural L - tryptophan derivative, which is sequentially subjected to formylation by adopting a cheap and easily available substituted indole compound as a raw material. Cyclization, ring opening, asym
Access to Polycyclic Sulfonyl Indolines via Fe(II)-Catalyzed or UV-Driven Formal [2 + 2 + 1] Cyclization Reactions of N-((1H-indol-3-yl)methyl)propiolamides with NaHSO3
Lu, Lin,Luo, Chenguang,Peng, Hui,Jiang, Huanfeng,Lei, Ming,Yin, Biaolin
supporting information, p. 2602 - 2605 (2019/04/30)
A variety of structurally novel polycyclic sulfonyl indolines have been synthesized via FeCl2-catalyzed or UV-driven intramolecular formal [2 + 2 + 1] dearomatizing cyclization reactions of N-(1H-indol-3-yl)methyl)propiolamides with NaHSO3 in an aqueous medium. The reactions involve the formation of one C-C bond and two C-S bonds in a single step.
