4771-80-6Relevant articles and documents
Blattel,Yates
, p. 1073 (1972)
Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels–Alder Reaction
Ochiai, Hidenori,Hayashi, Wakana,Nishiyama, Akira,Fujita, Ryunosuke,Kubota, Shunichi,Sasagawa, Miwa,Nishi, Tatsuya
supporting information, p. 1002 - 1009 (2022/02/09)
The optically active 3-cyclohexene-1-carboxylic acid was synthesized through a TiCl4-catalyzed diastereoselective Diels–Alder reaction utilizing lactic acid ester as a chiral auxiliary, which can be removed by washing with H2O. The (S)- and (R)-isomers were both derived from easily available ethyl l-lactate.
Organocatalyzed Aerobic Oxidation of Aldehydes to Acids
Dai, Peng-Fei,Qu, Jian-Ping,Kang, Yan-Biao
supporting information, p. 1393 - 1396 (2019/02/26)
The first example organocatalyzed aerobic oxidation of aldehydes to carboxylic acids in both organic solvent and water under mild conditions is developed. As low as 5 mol % N-hydroxyphthalimide was used as the organocatalyst, and molecular O2 was used as the sole oxidant. No transition metals or hazardous oxidants or cocatalysts were involved. A wide range of carboxylic acids bearing diverse functional groups were obtained from aldehydes, even from alcohols, in high yields.
Preparation method of cycloalkene carboxylic acid
-
Paragraph 0017; 0018; 0019; 0020, (2018/05/16)
The invention discloses a preparation method of cycloalkene carboxylic acid. The preparation method of cycloalkene carboxylic acid represented as the molecular formula I comprises steps as follows: unsaturated fatty acid represented as the molecular formula II and 1,3-butadiene are subjected to polymerization reaction for 1-3 h in a pressure vessel at the temperature of 120-300 DEG C with aqueousphase serving as a solvent in an inert environment with nitrogen pressurized gauge pressure being 1.0-5.0 MPa, then a synthesis liquid is transferred into a distillation kettle for distillation underthe negative-pressure condition, and cycloalkene carboxylic acid represented as the molecular formula I is obtained. Overall, the preparation method has the advantages as follows: reaction speed is high, reaction period is short, the reaction is performed in the aqueous phase, purification of cycloalkene carboxylic acid is facilitated, operation is simple and convenient, continuous production canbe executed, product quality is effectively improved, and use value is quite high.