477227-35-3

Basic information

• Product Name: {3-[4-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-phenyl}-pyridin-3-yl-methanol
• Synonyms: {3-[4-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-phenyl}-pyridin-3-yl-methanol
• CAS NO: 477227-35-3
• Molecular Weight: 493.721
• Mol File: 477227-35-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {3-[4-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-phenyl}-pyridin-3-yl-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: {3-[4-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-phenyl}-pyridin-3-yl-methanol(477227-35-3)
• EPA Substance Registry System: {3-[4-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-phenyl}-pyridin-3-yl-methanol(477227-35-3)

Safety Data

• Hazardous Substances Data: 477227-35-3(Hazardous Substances Data)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 442912-96-1 [4-(3-bromo-phenyl)-but-3-enyloxy]-tert-butyl-diphenyl-silane 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 442912-94-9 (E)-4-(3-Bromo-phenyl)-but-3-enoic acid ethyl ester 
• 442912-95-0 (E)-4-(3-Bromo-phenyl)-but-3-en-1-ol 

Downstream Products

• 476686-88-1 {3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone 
• 442912-97-2 [3-(4-hydroxy-butyl)-phenyl]-pyridin-3-yl-methanone 
• 477231-12-2 {3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol 

Relevant articles and documents

Novel Agents Combining Platelet Activating Factor (PAF) Receptor Antagonist with Thromboxane Synthase Inhibitor (TxSI)

Compounds 1 or 2 which possess dual-acting PAF antagonist/TxSI in a previous paper were modified and evaluated for the dual-acting activity. It was found that several compounds were potent dual-acting PAF antagonist/TxSI in and ex vivo. 6-(2-Chlorophenyl)-3-[4-[(E/Z)-6-ethoxycarbonyl-1-(3-pyridyl)-1- hexenyl]phenylmethyl]-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido[4′, 3′: 4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine (12) is excellent orally dual-acting PAF antagonist/TxSI.