477313-05-6Relevant articles and documents
(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine
Wu, Yong-Jin,Boissard, Christopher G.,Greco, Corinne,Gribkoff, Valentin K.,Harden, David G.,He, Huan,L'Heureux, Alexandre,Kang, Shing Hong,Kinney, Gene G.,Knox, Ronald J.,Natale, Joanne,Newton, Amy E.,Lehtinen-Oboma, Sanna,Sinz, Michael W.,Sivarao, Digavalli V.,Starrett Jr., John E.,Sun, Li-Qiang,Tertyshnikova, Svetlana,Thompson, Mark W.,Weaver, David,Wong, Henry S.,Zhang, Lei,Dworetzky, Steven I.
, p. 3197 - 3200 (2003)
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenyl-acrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride.