477947-68-5

Basic information

• Product Name: diphenylmethyl 6β-[(R)-2-(diphenylmethylamino)-2-(4-hydroxyphenyl)acetamido]penicillanate
• Synonyms: diphenylmethyl 6β-[(R)-2-(diphenylmethylamino)-2-(4-hydroxyphenyl)acetamido]penicillanate
• CAS NO: 477947-68-5
• Molecular Weight: 697.855
• Mol File: 477947-68-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diphenylmethyl 6β-[(R)-2-(diphenylmethylamino)-2-(4-hydroxyphenyl)acetamido]penicillanate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenylmethyl 6β-[(R)-2-(diphenylmethylamino)-2-(4-hydroxyphenyl)acetamido]penicillanate(477947-68-5)
• EPA Substance Registry System: diphenylmethyl 6β-[(R)-2-(diphenylmethylamino)-2-(4-hydroxyphenyl)acetamido]penicillanate(477947-68-5)

Safety Data

• Hazardous Substances Data: 477947-68-5(Hazardous Substances Data)

Upstream product

• 26787-78-0 amoxicillin 
• 90-99-3 diphenylchloromethane 

Downstream Products

• 477947-74-3 C₅₇H₅₂N₄O₁₃S 
• 477947-69-6 (2R,5R)-3-[2-{4-[(R)-(Benzhydryl-amino)-((2S,5R,6R)-2-benzhydryloxycarbonyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-methyl]-phenoxy}-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 477947-77-6 3-{4-[(benzhydryl-amino)-(2-benzhydryloxycarbonyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-methyl]-phenoxymethyl}-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Design, synthesis, and biological evaluation of a series of β-lactam-based prodrugs

By use of pro-dual-drug concept the synthesis of 6-β-[(R)-2-(clavaminio-9-N-yl)-2-(4-hydroxyphenylacetamido)]penicillanic acid (10), 6-β-[(R)-2-(amino)-2-(4-(clavulano-9-O-yl)phenylacetamido)]penicillanic acid (13), (Z)-4-[2-(amoxycillin-4-O-yl)ethylidene]-2-(clavulano-9-O-yl)-3-methoxy- Δα,β-butenolide (19), and 3-[(amoxicillin-4-O-yl)methyl]-7-(phenoxyacetamido)-(1-oxo)-3-cephem-4- carboxylic acid (23) was accomplished. Unlike penicillin G, ampicillin, or amoxicillin, these four heretofore undescribed compounds 10, 13, 19, and 23 showed notable activity against β-lactamase (βL) producing microorganisms, Staphylococcus aureus A9606, S. aureus A15091, S. aureus A20309, S. aureus 95, Escherichia coli A9675, E. coli A21223, E. coli 27C7, Pseudomonas aeruginosa 18S-H, and Klebsiella pneumoniae A20634 TEM. In comparison with amoxicillin (9), α-amino-substituted compound 10 and butenolide derivative 19 showed a broadened spectrum of antibacterial activity; yet they were found to be less active than 13 and 23. Like clavulanic acid (7) or cephalosporin-1-oxide (21), the newly synthesized compounds 10, 13, 15, 16, 19, or 23 functioned as potent inhibitors of various bacterial βLs.