478-42-2

Basic information

• Product Name: 7-Methyl-4-hydroxy-9-methoxy-5H-furo[3,2-g][1]benzopyran-5-one
• Synonyms: 4-Hydroxy-9-methoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one;5-Norkhellin;7-Methyl-4-hydroxy-9-methoxy-5H-furo[3,2-g][1]benzopyran-5-one;Khellinol
• CAS NO: 478-42-2
• Molecular Formula: C₁₃H₁₀O₅
• Molecular Weight: 246.2155
• Mol File: 478-42-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 299.2°Cat760mmHg
• Flash Point: 134.8°C
• Appearance: /
• Density: 1.411g/cm³
• Vapor Pressure: 0.000679mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 7-Methyl-4-hydroxy-9-methoxy-5H-furo[3,2-g][1]benzopyran-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methyl-4-hydroxy-9-methoxy-5H-furo[3,2-g][1]benzopyran-5-one(478-42-2)
• EPA Substance Registry System: 7-Methyl-4-hydroxy-9-methoxy-5H-furo[3,2-g][1]benzopyran-5-one(478-42-2)

Safety Data

• Hazardous Substances Data: 478-42-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10O5/c1-6-5-8(14)9-10(15)7-3-4-17-11(7)13(16-2)12(9)18-6/h3-5,15H,1-2H3

Upstream product

• 82-02-0 Khellin 
• 4481-60-1 5-norvisnagin 
• 2159-83-3 4,9-Dihydroxy-7-methyl-5H-furo<3,2-g><1>benzopyran-5-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 854460-03-0 1-(4-benzyloxy-6-hydroxy-7-methoxy-benzofuran-5-yl)-butane-1,3-dione 
• 854460-08-5 1-(4-benzyloxy-6,7-dimethoxy-benzofuran-5-yl)-butane-1,3-dione 
• 102706-17-2 4-ethoxy-9-methoxy-7-trans-styryl-furo[3,2-g]chromen-5-one 
• 114553-00-3 4-(diethylcarbamoyl-methoxy)-9-methoxy-7-trans-styryl-furo[3,2-g]chromen-5-one 
• 1158849-71-8 9-methoxy-7-methyl-4-(4-phenoxybutoxy)-5H-furo[3,2-g][1]benzopyran-5-one 
• 119104-31-3 1-(4-benzyloxy-6-hydroxy-7-methoxy-benzofuran-5-yl)-ethanone 

Relevant articles and documents

4-Phenoxybutoxy-substituted heterocycles - A structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3

The voltage-gated potassium channel Kv1.3 constitutes an attractive pharmacological target for the treatment of effector memory T cell-mediated autoimmune diseases such as multiple sclerosis and psoriasis. Using 5-methoxypsoralen (5-MOP, 1), a compound isolated from Ruta graveolens, as a template we previously synthesized 5-(4-phenoxybutoxy)psoralen (PAP-1, 2) which inhibits Kv1.3 with an IC50 of 2 nM. Since PAP-1 is more than 1000-fold more potent than 5-MOP, we here investigated whether attaching a 4-phenoxybutoxy side chain to other heterocyclic systems would also produce potent Kv1.3 blockers. While 4-phenoxybutoxy-substituted quinolines, quinazolines and phenanthrenes were inactive, 4-phenoxybutoxy-substituted quinolinones, furoquinolines, coumarins or furochromones inhibited Kv1.3 with IC50s of 150 nM to 10 μM in whole-cell patch-clamp experiments. Our most potent new compound is 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromene-7-thione (73, IC50 17 nM), in which the carbonyl oxygen of PAP-1 is replaced by sulfur. Taken together, our results demonstrate that the psoralen system is a crucial part of the pharmacophore of phenoxyalkoxypsoralen-type Kv1.3 blockers.

A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone

The voltage-gated potassium channel Kv1.3 constitutes an attractive target for the selective suppression of effector memory T cells in autoimmune diseases. We have previously reported the natural product khellinone, 1a, as a versatile lead molecule and id

UV-A Photolysis of Khellin: Products and Reaction Mechanism

Photolysis at 365 nm of khellin in various solvents was studied: the degradation rate strongly depends on solvent but not on polarity, since it is related to the singlet oxygen lifetime in each solvent.Eight products were isolated and characterized, some of which had previously been described as coming from chemical oxidation of khellin.Both facts support an oxic pathway for photolysis involving singlet oxygen and leading to unstable intermediates.These are rapidly decomposed by nucleophiles, suggesting possible interference - if they are also formed in vivo - with physiological processes during photochemotherapeutic treatment with khellin.