478-57-9 Usage
Description
Aporphine is an isoquinoline alkaloid that is the N-methyl derivative of 5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline. It is a naturally occurring compound found in various plants and has a wide range of applications in different industries.
Uses
Used in Pharmaceutical Industry:
Aporphine is used as a pharmaceutical compound for its potential therapeutic properties. It has been found to have various biological activities, such as anti-inflammatory, analgesic, and antipyretic effects. Additionally, it has been studied for its potential use in the treatment of neurological disorders, such as Parkinson's disease, due to its ability to modulate dopaminergic pathways.
Used in Cosmetic Industry:
Aporphine is used as a cosmetic ingredient for its potential skin-soothing and anti-aging properties. It has been found to have antioxidant and anti-inflammatory effects, which can help protect the skin from environmental stressors and promote a more youthful appearance.
Used in Agrochemical Industry:
Aporphine is used as an agrochemical compound for its potential insecticidal and pesticidal properties. It has been found to have neurotoxic effects on certain insects, making it a potential candidate for use in pest control strategies.
Used in Research and Development:
Aporphine is used as a research compound for the development of new drugs and therapies. Its unique chemical structure and biological activities make it an interesting target for further investigation and potential application in various fields, such as medicine, agriculture, and cosmetics.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 6, p. 91, 1963 DOI: 10.1021/jm00338a001
Check Digit Verification of cas no
The CAS Registry Mumber 478-57-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 478-57:
(5*4)+(4*7)+(3*8)+(2*5)+(1*7)=89
89 % 10 = 9
So 478-57-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H17N/c1-18-10-9-12-6-4-8-15-14-7-3-2-5-13(14)11-16(18)17(12)15/h2-8,16H,9-11H2,1H3
478-57-9Relevant articles and documents
Synthesis of Aporphine Analogues via Palladium-Catalyzed Intramolecular Aryl-Aryl Dehydrogenative Coupling
Su, Chen,Xu, Wen-Hua,Guo, Rui-Li,Zhang, Xing-Long,Zhu, Xue-Qing,Gao, Ya-Ru,Wang, Yong-Qiang
, p. 13618 - 13630 (2021/09/28)
Reported herein is an intramolecular dehydrogenative coupling of two inert aryl C-H bonds for the synthesis of aporphine analogues. The process represents a novel tool for the preparation of aporphines via palladiun-catalyzed C-H bond activation. The present reaction is compatible with various functional groups, and the coupling products have been further applied for the synthesis of natural products aporphine and zenkerine.
Phenanthrene derivatives for use as medicaments
-
Page/Page column, (2014/07/07)
Phenanthrene derivatives of formula I for use as medicaments. The present invention refers to phenanthrene derivatives for use as medicaments, mainly in the prevention and/or treatment of DM1, HDL2, SCA8, DM2, SCA3, FXTAS, FTD/ALS, and SCA31. In a preferred embodiment, phenanthrene derivatives of the invention are also used as antimyotonic agents.
Synthesis of (±)-aporphine utilizing Pictet-Spengler and intramolecular phenol ortho-arylation reactions
Cuny, Gregory D.
, p. 5167 - 5170 (2007/10/03)
A synthesis of the alkaloid (±)-aporphine is reported. The initial key step of the synthesis involves a Pictet-Spengler cyclization of N-tosyl tyramine with 2-bromophenylacetaldehyde in trifluoroacetic acid. This step was followed by the second strategic
