478-73-9 Usage
General Description
Methyl (1R,2S,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate, also known as pseudococaine, is a chemical compound that is structurally similar to cocaine. It is a derivative of the naturally occurring cocaine alkaloid, and it exhibits similar pharmacological effects in the central nervous system. Pseudococaine has been studied for its potential as a local anesthetic and analgesic, with some research suggesting that it may have less of a potential for abuse and addiction compared to cocaine. However, further studies are needed to fully understand its pharmacological properties and potential medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 478-73-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 478-73:
(5*4)+(4*7)+(3*8)+(2*7)+(1*3)=89
89 % 10 = 9
So 478-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15-/m0/s1
478-73-9Relevant articles and documents
Asymmetric synthesis of the tropane alkaloid (+)-pseudococaine via ring-closing iodoamination
Brock, E. Anne,Davies, Stephen G.,Lee, James A.,Roberts, Paul M.,Thomson, James E.
supporting information; experimental part, p. 4278 - 4281 (2012/09/22)
Ring-closing iodoamination of tert-butyl 2-hydroxy-7-[N-methyl-N-(α- methyl-p-methoxybenzyl)amino]cyclohept-3-ene-1-carboxylates proceeds with concomitant loss of the N-α-methyl-p-methoxybenzyl group to give the corresponding 8-azabicyclo[3.2.1]octane sca
A PLE-based resolution of cocaine, pseudococaine, and 6-and 7-methoxylated cocaine analogues
Kozikowski,Simoni,Baraldi,Lampronti,Manfredini
, p. 441 - 444 (2007/10/03)
The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.
