478148-62-8

Basic information

• Product Name: Furo[2,3-c]pyridine-5-carboxylic acid (9CI)
• Synonyms: Furo[2,3-c]pyridine-5-carboxylic acid (9CI)
• CAS NO: 478148-62-8
• Molecular Formula: C₈H₅NO₃
• Molecular Weight: 163.1302
• Product Categories: GLYCINESCAFFOLD
• Mol File: 478148-62-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 366.789 °C at 760 mmHg
• Flash Point: 175.628 °C
• Appearance: /
• Density: 1.455
• Storage Temp.: 2-8°C
• PKA: 1.06±0.30(Predicted)
• CAS DataBase Reference: Furo[2,3-c]pyridine-5-carboxylic acid (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-c]pyridine-5-carboxylic acid (9CI)(478148-62-8)
• EPA Substance Registry System: Furo[2,3-c]pyridine-5-carboxylic acid (9CI)(478148-62-8)

Safety Data

• Hazardous Substances Data: 478148-62-8(Hazardous Substances Data)

Usage

General Description

Furo[2,3-c]pyridine-5-carboxylic acid (9CI) is a chemical compound belonging to the class of pyridines. It consists of a fused furo[2,3-c]pyridine ring system with a carboxylic acid substituent at the 5-position. Furo[2,3-c]pyridine-5-carboxylic acid (9CI) is a heterocyclic organic molecule with potential pharmacological and biological activities. It may be used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Furo[2,3-c]pyridine-5-carboxylic acid (9CI) has also been studied for its potential medical applications, including its role as an inhibitor of certain enzyme activities or as a ligand in metal coordination chemistry. Its chemical structure and properties make it a versatile and valuable compound in various scientific and industrial applications.

Upstream product

• 441044-90-2 [7-chloro-2-(trimethylsilyl)furo[2,3-c]pyridin-5-yl]methanol 
• 478148-59-3 5-hydroxymethyl-2-trimethylsilyl-furo[2,3-c]pyridine 
• 478148-61-7 furo[2,3-c]pyridine-5-carbaldehyde 
• 7758-19-2 sodium chlorite 
• 208519-38-4 2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol 
• 208519-37-3 2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine 
• 208519-39-5 (7-chlorofuro[2,3-c]pyridin-5-yl)methanol 
• 208519-41-9 2-chloro-6-(hydroxymethyl)-3-pyridinol 
• 6636-78-8 2-chloro-3-hydroxypyridine 
• 478148-60-6 furo[2,3-c]pyridin-5-yl methanol 

Downstream Products

• 478149-53-0 PHA-543613 

Relevant articles and documents

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5- carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure-activity relationship

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been identified as a potential treatment of cognitive deficits in schizophrenia. Compound 14 is a potent and selective a7 nAChR agonist with an excellent in vitro profile. The compound is characterized by rapid brain penetration and high oral bioavailability in rat and demonstrates in vivo efficacy in auditory sensory gating and, in an in vivo model to assess cognitive performance, novel object recognition.

Substituted 7-aza[2.2.1]bicycloheptanes for the treatment of disease

The invention provides compounds of Formula I: which may be in the form of pharmaceutical acceptable salts or compositions, are useful in treating diseases or conditions in which α7 nicotinic acetylcholine receptors (nAChRs) are known to be involved.

Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease

The invention provides compounds of Formula I: 1where in W is 2These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.