478413-45-5

Basic information

• Product Name: Benzeneacetic acid, 2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-, methyl ester
• Synonyms: Methyl 2-(2-((6-(2-cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)acetate;BEN388;Benzeneacetic acid,2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-,methyl ester
• CAS NO: 478413-45-5
• Molecular Formula: C20H15N3O4
• Molecular Weight: 361.35100
• Mol File: 478413-45-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 508.1±50.0 °C(Predicted)
• Density: 1.34±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzeneacetic acid, 2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-, methyl ester(478413-45-5)
• EPA Substance Registry System: Benzeneacetic acid, 2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-, methyl ester(478413-45-5)

Safety Data

• Hazardous Substances Data: 478413-45-5(Hazardous Substances Data)

Upstream product

• 611-20-1 salicylonitrile 
• 484064-87-1 methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)acetate 
• 1193-21-1 4,6-dichloropyrimidine 
• 22446-37-3 methyl (2-hydroxyphenyl)acetate 
• 215934-32-0 azoxystrobin 

Downstream Products

• 215934-32-0 azoxystrobin 

Relevant articles and documents

PROCESS FOR PREPARING 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES

Process for preparing 4,6-bis(aryloxy)pyrimidine derivatives A process is provided for preparing 4,6-bis(aryloxy)pyrimidine derivatives. The process is conducted in water as reaction medium and catalyzed by one or more tertiary-amine catalyst(s). It has been found that a water based reaction substantially free of organic solvents can be carried out providing excellent yields by the addition of one or more tertiary-amine catalysts to the reaction medium. This provides a clean reaction and produces the desired product in high yields.

PREPARATION METHODS OF AZOXYSTROBIN AND ITS ANALOGS

Preparation method of a compound of general formula (I) comprises the following steps: (1) a compound of general formula (II) reacts with a formylating agent in an aprotic solvent at a temperature between ?20° C. and 200° C. in the presence of a Lewis acid, then an organic base is added to promote the reaction to obtain an intermediate product; (2) the above intermediate product reacts with a methylating agent in the presence of an alkali at a temperature between ?20° C. and 100° C. to obtain the compound of formula (I).