478646-33-2

Basic information

• Product Name: (S)-3-N-CBZ-AMINO-PIPERIDINE
• Synonyms: (S)-benzyl piperidin-3-ylcarbamate;benzyl N-(piperidin-3-yl)carbaMate;(3S)-3-[(Benzyloxycarbonyl)amino]piperidine;Benzyl (S)-piperidin-3-ylcarbamate;N-(3S)-3-Piperidinylcarbamic acid phenylmethyl ester;(S)-3-(Cbz-aMino)piperidine;(S)-3-(Cbz-aMino)piperidi...;benzyl N-[(3S)-piperidin-3-yl]carbaMate
• CAS NO: 478646-33-2
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.3
• Mol File: 478646-33-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 396.3 °C at 760 mmHg
• Flash Point: 193.5 °C
• Appearance: /
• Density: 1.13
• Vapor Pressure: 1.73E-06mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.16±0.20(Predicted)
• CAS DataBase Reference: (S)-3-N-CBZ-AMINO-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-N-CBZ-AMINO-PIPERIDINE(478646-33-2)
• EPA Substance Registry System: (S)-3-N-CBZ-AMINO-PIPERIDINE(478646-33-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• Hazardous Substances Data: 478646-33-2(Hazardous Substances Data)

Usage

General Description

(S)-3-N-Cbz-amino-piperidine, also known as (S)-3-[(Benzyloxy)carbonylamino]piperidine, is a synthetic organic compound. The term "Cbz" in its name denotes the presence of a carbobenzyloxy protective group, used to protect or block the reactive sites in a molecule during a chemical reaction. (S)-3-N-Cbz-amino-piperidine belongs to the family of piperidines, a group of organic compounds containing a piperidine ring, a common feature in many pharmaceuticals and alkaloids. Its chemical formula is C14H18N2O2 and its molecular weight is 246.303 g/mol. (S)-3-N-Cbz-amino-piperidine is used in medicinal chemistry, specifically in the synthesis of various pharmaceutical drugs.

InChI:InChI=1/C13H18N2O2/c16-13(15-12-7-4-8-14-9-12)17-10-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2,(H,15,16)/t12-/m0/s1

Upstream product

• 95582-17-5 (S)-3-[[(phenylmethoxy)carbonyl]amino]-2-oxopiperidine 
• 625471-18-3 tert-butyl (3S)-3-aminopiperidine-1-carboxylate 
• 1002360-09-9 tert-butyl (3S)-3-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1912445-55-6 (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide 
• 1620240-06-3 C₃₉H₃₅N₇O₅ 
• 1620239-28-2 benzyl {(3S)-1-[3-({[3-{[(benzyloxy)carbonyl]amino}-7-(cyanomethyl)quinolin-2-yl]carbonyl}amino)pyridin-4-yl]piperidin-3-yl}carbamate 
• 1620240-05-2 benzyl [(3S)-1-(3-amino-5-cyanopyridin-4-yl)piperidin-3-yl]carbamate 
• 1620240-04-1 benzyl [(3S)-1-(3-cyano-5-nitropyridin-4-yl)piperidin-3-yl]carbamate 
• 1620239-13-5 benzyl [(3S)-1-(3-{[(3-{[(benzyloxy)carbonyl]amino}-7-bromoquinolin-2-yl)carbonyl]amino}pyridin-4-yl)piperidin-3-yl]carbamate 
• 1620239-10-2 benzyl [(3S)-1-(3-aminopyridin-4-yl)piperidin-3-yl]carbamate 
• 1620239-34-0 benzyl [(3S)-1-(3-{[(3-{[(benzyloxy)carbonyl]amino}-6-fluoro-7-vinylquinolin-2-yl)carbonyl]amino}pyridin-4-yl)piperidin-3-yl]carbamate 
• 1620240-03-0 benzyl [(3S)-1-(3-bromo-5-nitropyridin-4-yl)piperidin-3-yl]carbamate 
• 1620239-09-9 benzyl [(3S)-1-(3-nitropyridin-4-yl)piperidin-3-yl]carbamate 
• 927389-28-4 7-[(3S)-3-benzyloxycarbonylaminopiperidin-1-yl]-2-tert-butyl-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile 

Relevant articles and documents

INHIBITORS OF CYCLIN DEPENDNT KINASE 7 (CDK7)

The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.