4787-77-3

Basic information

• Product Name: 2-(1-PYRROLIDINO)PHENOL
• Synonyms: N-(2-HYDROXYPHENYL)PYRROLIDINE;2-(1-PYRROLIDINO)PHENOL;2-PYRROLIDIN-1-YL-PHENOL;2-TETRAHYDRO-1H-PYRROL-1-YLPHENOL;1-(2-Hydroxyphenyl)pyrrolidine;2-Pyrrolidinophenol;2-(1-Pyrrolidinyl)phenol, 98%;2-(1-Pyrrolidino)phenol,98%
• CAS NO: 4787-77-3
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Product Categories: Phenyls & Phenyl-Het
• Mol File: 4787-77-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 108-112 °C
• Boiling Point: 279.1 °C at 760 mmHg
• Flash Point: 139.6 °C
• Appearance: beige to brown crystalline powder
• Density: 1.146 g/cm³
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.594
• PKA: 10.30±0.30(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 135437
• CAS DataBase Reference: 2-(1-PYRROLIDINO)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-PYRROLIDINO)PHENOL(4787-77-3)
• EPA Substance Registry System: 2-(1-PYRROLIDINO)PHENOL(4787-77-3)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22-52-41-37/38-22
• Safety Statements: 36/37/39-26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 4787-77-3(Hazardous Substances Data)

Usage

Chemical Properties

beige to brown crystalline powder

InChI:InChI=1/C10H13NO/c12-10-6-2-1-5-9(10)11-7-3-4-8-11/h1-2,5-6,12H,3-4,7-8H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 95-55-6 2-amino-phenol 
• 591-27-5 m-Hydroxyaniline 
• 90-04-0 2-methoxy-phenylamine 
• 109-99-9 tetrahydrofuran 
• 4787-76-2 1-(2-methoxyphenyl)pyrrolidine 

Downstream Products

• 109366-12-3 1-(2-dimethylcarbamoyloxy-phenyl)-1-methyl-pyrrolidinium; iodide 
• 20925-25-1 2-(pyrrolidin-1-yl)benzonitrile 
• 4787-78-4 ethyl 2-[2-(pyrrolidin-1-yl)phenoxy]acetate 
• 223133-43-5 t-butyl N-[2-nitro-5-(2-pyrrolidinophenoxy)phenyl]-N-methylcarbamate 
• 101264-86-2 dimethyl-carbamic acid-(2-pyrrolidino-phenyl ester) 

Relevant articles and documents

METHOD FOR PRODUCING AN ARENE WITH AN AROMATIC C-N BOND ORTHO TO AN AROMATIC C-O BOND

A method for producing an arene with an aromatic C—N bond ortho to an aromatic C—O bond from a hydroxy arene comprising said aromatic C—O bond is provided. This method comprising the steps a) ortho-oxygenating the hydroxy arene to produce an ortho-quinone, b) condensating the ortho-quinone with a nitrogen nucleophile to generate a compound of Formula (IVa) or (IVb), and c) allowing 1,5-hydrogen atom shift of the compound of Formula (IVa) or (IVb), thereby producing arenes with a C—N bond ortho to a C—O bond of Formula (Va) and (Vb), respectively:

Total synthesis of abyssomicin C, atrop-abyssomicin C, and abyssomicin D: Implications for natural origins of atrop-abyssomicin C

In this article, the total syntheses of the antibiotic abyssomicin C (1) and its biologically inactive sibling abyssomicin D (3) are described. A number of unforseen roadblocks in our synthetic plan encouraged innovation, which culminated in the discovery

gem-cyclodialkylation A facile synthetic route to N-substituted heterocycles

N-alkylated and N-arylated pyrroles, pyrrolidines, and piperidines are synthesized in high yield by the reaction between cyclic ethers and primary amines over a heterogeneous titania catalyst.