478832-10-9

Basic information

• Product Name: 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine
• Synonyms: 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine;5-Amino-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole;1-(oxan-2-yl)-1H-indazol-5-aMine;5-Amino-1-(tetrahydropyranyl)-1H-indazole
• CAS NO: 478832-10-9
• Molecular Formula: C₁₂H₁₅N₃O
• Molecular Weight: 217.27
• Mol File: 478832-10-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 428.7 °C at 760 mmHg
• Flash Point: 213.1 °C
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 1.49E-07mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine(478832-10-9)
• EPA Substance Registry System: 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine(478832-10-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 478832-10-9(Hazardous Substances Data)

Usage

General Description

1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine is a chemical compound with the molecular formula C15H18N2O. It is a member of the indazole class of compounds, which are commonly used in pharmaceutical research and drug development. This specific compound contains a tetrahydro-2H-pyran-2-yl group attached to the 1-position of the indazole ring, and an amine functional group at the 5-position. While the exact properties and uses of this specific compound are not readily available, indazole derivatives are known to exhibit a wide range of biological activities, including anticancer, anti-inflammatory, and antimicrobial properties. Further research and testing would be needed to fully understand the potential pharmacological and toxicological effects of 1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine.

InChI:InChI=1/C12H15N3O/c13-10-4-5-11-9(7-10)8-14-15(11)12-3-1-2-6-16-12/h4-5,7-8,12H,1-3,6,13H2

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 5401-94-5 5-nitroindazole 
• 150187-64-7 5-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 

Downstream Products

• 1574357-80-4 1-(4-((2-((1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(tert-butyl)-1-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazol-5-yl)urea 
• 1574358-60-3 1-(3-(tert-butyl)-1-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-((1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea 
• 1435462-95-5 2-methyl-1-(3-methylbutyl)-4-phenyl-7-{[1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl]amino}-1,4-dihydropyrido[3,4-b]pyrazin-3(2H)-one 

Relevant articles and documents

HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE

This invention relates to novel compounds and pharmaceutical compositions comprising. Compounds of the invention useful as modulators of Rho-associated protein kinase (ROCK), for example ROCK1 and/or ROCK2 inhibitors. Methods of treatment employing the compounds are also contemplated by the present invention. The compounds of the invention are useful in treating ROCK mediated diseases.

PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS

Compounds of formula (I) wherein R1, R2, J, Q, V, X, Y and Z are defined herein are disclosed. The compounds are inhibitors of the family of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha sub-type thereof, and of Syk kinase and the Src family of tyrosine kinases. The compounds may be used in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, in particular inflammatory diseases of the lung, such as asthma and COPD, as well as those of the gastrointestinal tract, such as ulcerative colitis and Crohn's disease and of the eye, such as uveitis.