4792-10-3

Basic information

• Product Name: 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester
• CAS NO: 4792-10-3
• Molecular Formula: C21H26N2O6
• Molecular Weight: 402.447
• Mol File: 4792-10-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester(4792-10-3)
• EPA Substance Registry System: 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester(4792-10-3)

Safety Data

• Hazardous Substances Data: 4792-10-3(Hazardous Substances Data)

Usage

Description

1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester is a complex organic compound that features a pyrrole ring, a propanoic acid group, methylene, formyl, and methyl groups. As a dimethyl ester, it possesses two ester functional groups. This unique structure and composition may endow it with potential applications in the pharmaceutical and chemical industries. It can serve as a building block for synthesizing more complex organic molecules and could exhibit biological activity that is valuable for drug development. However, further research is necessary to explore its full potential and effects.

Uses

Used in Pharmaceutical Industry:
1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester is used as a building block for the synthesis of complex organic molecules, which may have potential applications in drug development due to its unique structure and properties.
Used in Chemical Industry:
1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester is used as a precursor in the synthesis of various organic compounds, taking advantage of its versatile chemical structure and functional groups.

Upstream product

• 30103-05-0 5,5'-bis(tert-butoxycarbonyl)-4,4'-dimethyl-3,3-bis(2-(methoxycarbonyl)ethyl)-2,2'-dipyrrylmethane 
• 149-73-5 trimethyl orthoformate 
• 54605-86-6 3-(5-benzyloxycarbonyl-2-bromomethyl-4-methyl-pyrrol-3-yl)-propionic acid methyl ester 
• 809-27-8 4,4'-bis-(2-methoxycarbonyl-ethyl)-3,3'-dimethyl-5,5'-methanediyl-bis-pyrrole-2-carboxylic acid 
• 859-38-1 benzyl 5-acetoxymethyl-4-(2-methoxycarbonylethyl)-3-methylpyrrole-2-carboxylate 
• 30089-44-2 tert-butyl 5-acetoxymethyl-4-(2-methoxycarbonylethyl)-3-methyl-pyrrole-2-carboxylate 
• 60024-89-7 4-(2-methoxycarbonylethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 992-36-9 dibenzyl 3,3'-bis(2-methoxycarbonylethyl)-4,4'-dimethyl-2,2'-pyrromethane-5,5'-dicarboxylate 
• 20303-31-5 benzyl 4-(2-methoxycarbonylethyl)-3,5-dimethylpyrrole-2-carboxylate 
• 802-52-8 3,3'-dimethoxycarbonylethyl-4,4'-dimethyl-2,2'-dipyrromethane 
• 76-05-1 trifluoroacetic acid 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 33909-86-3 dimethyl 3,7,13,17-tetramethylporphyrin-2,18-dipropionate 
• 79760-26-2 5,5'-diformyl-4,4'-dimethyl-5,5'-bis(2-carboxyethyl)-2,2'-dipyrrylmethane 
• 10591-31-8 2,4-diacetyl-6,7-bis<2-(methoxycarbonyl)ethyl>-1,3,5,8-tetramethylporphyrin 
• 5594-29-6 3,3'-[7,12-bis-(1-hydroxy-ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-diyl]-bis-propionic acid dimethyl ester 
• 53872-58-5 3-(2-chloroethyl)-8,13,17-tris(2-methoxycarbonylethyl)-2,7,12,18-tetramethylporphyrin 
• 42607-18-1 harderoporphyrinogen-III 
• 30783-27-8 3-vinyl-2,7,12,18-tetramethylporphyrin-8,13,17-tripropionic acid 
• 553-12-8 protoporphyrin IX 
• 992-32-5 13,17-Diethyl-3,7-bis(2-methoxycarbonylethyl)-2,8,12,18-tetramethylporphyrin 
• 16132-39-1 5'-formyl-3,3'-bis(2-methoxycarbonylethyl)-4,4'-dimethylpyrromethane-5-carboxylic acid 

Relevant articles and documents

Corrole-Substituted Fluorescent Heme Proteins

Although fluorescent proteins have been utilized for a variety of biological applications, they have several optical limitations, namely weak red and near-infrared emission and exceptionally broad (>200 nm) emission profiles. The photophysical properties of fluorescent proteins can be enhanced through the incorporation of novel cofactors with the desired properties into a stable protein scaffold. To this end, a fluorescent phosphorus corrole that is structurally similar to the native heme cofactor is incorporated into two exceptionally stable heme proteins: H-NOX from Caldanaerobacter subterraneus and heme acquisition system protein A (HasA) from Pseudomonas aeruginosa. These yellow-orange emitting protein conjugates are examined by steady-state and time-resolved optical spectroscopy. The HasA conjugate exhibits enhanced fluorescence, whereas emission from the H-NOX conjugate is quenched relative to the free corrole. Despite the low fluorescence quantum yields, these corrole-substituted proteins exhibit more intense fluorescence in a narrower spectral profile than traditional fluorescent proteins that emit in the same spectral window. This study demonstrates that fluorescent corrole complexes are readily incorporated into heme proteins and provides an inroad for the development of novel fluorescent proteins.

Total synthesis of hematoporphyrin and protoporphyrin: A conceptually new approach

The total synthesis of protoporphyrin IX and its disodium salt using a new alternative method to the classical MacDonald condensation is reported. The key step is the reaction of the new unsymmetrical diiodo dipyrrylmethane 1 with the known dipyrrylmethane 2. Coupling of the two fragments leads directly to porphyrin 3 without the need of an oxidizing agent. The new methodology is well suited for the synthesis of protoporphyrin IX derivatives on a multi 100 g scale in good quality without the need for chromatography. Furthermore, these preparations are completely free of any contaminant of animal origin, which represents a real improvement in the manufacturing of protoporphyrin IX derivatives.

Process For Preparing Porphyrin Derivatives, Such As Protoporphyrin (IX) And Synthesis Intermediates

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R′ are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R′b is as defined above for (I), and a dipyrromethane of formula (III): in which R″ is as defined in claim 1, and also the compounds of formula (III).