4792-58-9 Usage
Description
ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE is an organic compound with a diverse range of applications in various industries, particularly in the pharmaceutical and chemical sectors. It is known for its ability to serve as a reactant in the preparation of ligands with binding specificity towards the GABA receptor, as well as for its potential use in developing inhibitors and other therapeutic agents.
Uses
Used in Pharmaceutical Industry:
ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE is used as a reactant for the preparation of ligands with binding specificity towards the GABA receptor, which plays a crucial role in the central nervous system and is involved in various neurological disorders.
Used in Diabetes Management:
In the field of diabetes management, ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE is used as a precursor in the development of sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. These inhibitors help manage hyperglycemia in diabetes by blocking the reabsorption of glucose in the kidneys, thereby promoting its excretion through urine.
Used in Anticancer Applications:
ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE serves as a reactant in the synthesis of anticancer agents, which are designed to target and inhibit the growth and proliferation of cancer cells.
Used in HIV Treatment:
ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE is also utilized as a reactant in the development of integrase strand-transfer inhibitors (INSTIs), which are crucial in the treatment of HIV by inhibiting the integration of the viral genome into the host's DNA.
Used in Colon Cancer Treatment:
ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE is used as a reactant in the synthesis of inhibitors of the proliferation of colon cancer cells, contributing to the development of potential therapeutic agents for colon cancer treatment.
Used in the Development of GSK-3 Inhibitors:
ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE is employed as a reactant in the preparation of isomeridianin G, which acts as a GSK-3β inhibitor. GSK-3β inhibitors have potential applications in the treatment of various diseases, including neurodegenerative disorders and cancer.
Used in HIV-1 Integrase Inhibition:
ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE is used as a reactant in the development of HIV-1 integrase inhibitors, which play a vital role in the treatment of HIV by blocking the integration of the virus into the host's DNA.
Used in the Development of MK-2 Inhibitors:
ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE is also used as a reactant in the synthesis of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). MK-2 inhibitors have potential applications in the treatment of inflammatory diseases and cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 4792-58-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,9 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4792-58:
(6*4)+(5*7)+(4*9)+(3*2)+(2*5)+(1*8)=119
119 % 10 = 9
So 4792-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H13NO3/c1-3-16-12(14)11-7-8-6-9(15-2)4-5-10(8)13-11/h4-7,13H,3H2,1-2H3
4792-58-9Relevant articles and documents
From far west to east: Joining the molecular architecture of imidazole-like ligands in ho-1 complexes
Fallica, Antonino Nicolò,Floresta, Giuseppe,Greish, Khaled,Patamia, Vincenzo,Pittalà, Valeria,Rescifina, Antonio,Sorrenti, Valeria
, (2021/12/21)
HO-1 overexpression has been reported in several cases/types of human malignancies. Unfortunately, poor clinical outcomes are reported in most of these cases, and the inhibition of HO-1 is considered a valuable and proven anticancer approach. To identify
Synthesis method of indole-2-carboxylic acid and derivative thereof
-
Paragraph 0043-0049, (2019/02/21)
The invention relates to a synthesis method of indole-2-carboxylic acid and a derivative thereof, belonging to the field of organic synthesis. In the synthesis method, the indole-2-carboxylic acid isprepared through two steps of reaction with phenylhydrazine hydrochloride and ethyl pyruvate as raw materials and sulfuric acid as a catalyst. The synthesis method has a short process and uses fewer raw materials, the total yield of indole-2-carboxylic acid reaches 70% or above. The method can synthesize both indole-2-carboxylic acid and the derivative thereof, thereby being suitable for industrial production.
Preparation method for Arbidol intermediate
-
Paragraph 0020-0021; 0023; 0025, (2018/09/08)
The invention belongs to the field of medical intermediates, and particularly relates to a preparation method for an Arbidol intermediate. 5-methoxy-2-nitrophenol and ethyl acrylate are taken as synthesis raw materials, noble metal catalyst is added, hydrogen is introduced, reaction temperature and reaction time are optimized, catalytic hydrogenation reduction reaction is carried out, and finally,ethyl 5-methoxyindole-2-carboxylate is prepared. In a reaction process, no organic solvents need to be added, a preparation technology is simplified, an obtained product is purer, a yield is higher,in addition, a technology is simple, and the preparation method has an important meaning in the research of the Arbidol intermediate.
