479227-60-6Relevant articles and documents
Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation
Guo, Junqing,Watson, Andrew,Kempson, James,Carlsen, Marianne,Barbosa, Joseph,Stebbins, Karen,Lee, Deborah,Dodd, John,Nadler, Steven G.,McKinnon, Murray,Barrish, Joel,Pitts, William J.
, p. 1935 - 1938 (2009)
A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.
