479408-24-7

Basic information

• Product Name: 8-(N-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2'-deoxyguanosine
• Synonyms: 8-(N-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2'-deoxyguanosine
• CAS NO: 479408-24-7
• Molecular Weight: 1067.49
• Mol File: 479408-24-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-(N-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2'-deoxyguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(N-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2'-deoxyguanosine(479408-24-7)
• EPA Substance Registry System: 8-(N-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2'-deoxyguanosine(479408-24-7)

Safety Data

• Hazardous Substances Data: 479408-24-7(Hazardous Substances Data)

Upstream product

• 479408-22-5 O⁶-benzyl-8-bromo-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 479408-21-4 3',5'-O,O'-bis(tert-butyldimethylsilyl)-8-bromo-2'-deoxyguanosine 
• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 603994-26-9 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-(8-azido-6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 603994-32-7 (2R,3S,5R)-5-(8-Amino-6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1133-80-8 2-bromo-9H-fluorene 
• 603994-27-0 6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine 
• 53-96-3 2-acetylaminofluorene 
• 479408-23-6 O⁶-benzyl-8-bromo-3′,5′-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2′-deoxyguanosine 
• 153-78-6 2-aminofluorene 

Downstream Products

• 479408-36-1 8-(N-acetyl-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine 
• 479408-42-9 8-(N-acetyl-2-amino-fluorene)-O⁶-benzyl-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine 
• 479408-35-0 8-(N-acetyl-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 479408-38-3 8-(N-acetyl-2-amino-fluorene)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine 
• 479408-37-2 8-(N-acetyl-2-amino-fluorene)-O⁶-benzyl-2'-deoxyguanosine 
• 37819-60-6 fluorene 
• 73051-69-1 2-fluoren 
• 479408-30-5 8-(N-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 

Relevant articles and documents

Chemical synthesis of 2′-deoxyguanosine-C8 adducts with heterocyclic amines: An application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Synthesis of 2′-deoxyguanosine-C8 adducts (dG-C8 adducts) with mutagenic/carcinogenic heterocyclic amines (HCAs) was achieved via the Buchwald-Hartwig arylamination reaction. By using tris-(dibenzylideneacetone) dipalladium (Pd2dba3)

Preparation of C8-amine and acetylamine adducts of 2′-deoxyguanosine suitably protected for DNA synthesis

(Equation presented) C8-Amine and acetylamine adducts of 2′-deoxyguanosine were synthesized. Our approach provides solutions for the coupling of aromatic amines to a protected 8-bromo-2′-deoxyguanosine derivative, for the selective acetylation of the coup