479413-68-8 Usage
Biological Activity
cuda is a soluble epoxide hydrolase (seh) inhibitor.epoxyeicosatrienoic acid metabolites of arachidonic acid, such as 11(12)-eet and 14(15)-eet, have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. soluble epoxide hydrolase (seh) can catalyze the conversion of eets to the corresponding dihydroxy eicosatrienoic acids thereby diminishing their activity.
in vitro
in a previous study, in order to test if the cuda’s mechanism of action is retained upon structural modification, the dissociation constants of cuda was evaluated for mouse seh. results showed that for cuda, competitive a tight-binding inhibition kinetic was obtained with r2 > 0.99. moreover, the ki value of 3.8 nm was obtained for cuda. in addition, it was found that cuda was an inhibitor of seh exhibiting ic50 values of 11.1 nm and 112 nm for the mouse and human enzymes, respectively [1].
IC 50
11.1 and 112 nm for the mouse and human soluble epoxide hydrolase, respectively
references
[1] c. morisseau, m. h. goodrow, j. w. newman, et al. structural refinement of inhibitors of urea-based soluble epoxide hydrolases. biochemical pharmacology 63, 1599-1608 (2002).
Check Digit Verification of cas no
The CAS Registry Mumber 479413-68-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,9,4,1 and 3 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 479413-68:
(8*4)+(7*7)+(6*9)+(5*4)+(4*1)+(3*3)+(2*6)+(1*8)=188
188 % 10 = 8
So 479413-68-8 is a valid CAS Registry Number.
