479691-42-4

Basic information

• Product Name: TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE
• Synonyms: 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE;1-Boc-4-(4-chloropyrimidin-2-yl)piperazine;4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate
• CAS NO: 479691-42-4
• Molecular Formula: C₁₃H₁₉ClN₄O₂
• Molecular Weight: 298.77
• Mol File: 479691-42-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 434.5°C at 760 mmHg
• Flash Point: 216.6°C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 9.46E-08mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.46±0.40(Predicted)
• CAS DataBase Reference: TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE(479691-42-4)
• EPA Substance Registry System: TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE(479691-42-4)

Safety Data

• Hazardous Substances Data: 479691-42-4(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate is a chemical compound with the molecular formula C15H22ClN5O2. It is a piperazine carboxylate ester derivative, containing a tert-butyl group and a chloropyrimidine substituent. TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE may be used in pharmacological research as a potential drug candidate or as a building block for the synthesis of various biologically active molecules. It is important to handle this compound with caution and follow proper safety protocols, as it may have hazardous properties.

InChI:InChI=1/C13H19ClN4O2/c1-13(2,3)20-12(19)18-8-6-17(7-9-18)11-15-5-4-10(14)16-11/h4-5H,6-9H2,1-3H3

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 3934-20-1 2,6-Dichloropyrimidine 
• 53788-49-1 tert-butyl 4-methylpiperazine-1-carboxylate 

Downstream Products

• 1185316-90-8 4-chloro-2-(piperazin- 1-yl)pyrimidine hydrochloride 
• 479691-64-0 4-[4-(3-chloro-benzylamino)-pyrimidin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 479691-44-6 4-[1-(2-Chloro-phenyl)-ethoxy]-2-piperazin-1-yl-pyrimidine 
• 1567326-99-1 tert-butyl 4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylate 
• 1567327-00-7 tert-butyl 4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylate 
• 1143578-98-6 4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide 
• 1143578-94-2 4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide 
• 1143578-90-8 4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide 
• 1143577-36-9 4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide 
• 1143623-67-9 4-(3,5-Difluorophenyl)-2-(piperazin-1-yl)pyrimidine 
• 1143623-66-8 4-(3,4-difluorophenyl)-2-(piperazin-1-yl)pyrimidine dihydrochloride 
• 1143623-65-7 4-(2,5-difluorophenyl)-2-(piperazin-1-yl)pyrimidine 
• 1143577-34-7 4-(2,4-difluorophenyl)-2-(piperazin-1-yl)pyrimidine 
• 1567327-01-8 tert-butyl 4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylate 

Relevant articles and documents

PIPERAZINE CYCLIC UREAS

Provided are piperazine cyclic urea compounds that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), pharmaceutically acceptable salts, hydrates and stereoisomers thereof. Provided are also pharmaceutical compositions, methods of making, and methods of use which include treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

AMIDE COMPOUND

An object of the present invention is to provide a novel fused-ring compound which has a FAAH inhibitory effect and is useful as an analgesic. The present invention relates to a compound represented by formula (I): wherein symbols are as defined in the specification, or salt thereof.