480-87-5 Usage
Description
(13S)-14-Deethylidene-13-hydroxy-17-norcrotalanan-11,15-dione is a complex chemical compound belonging to the class of crotalane diterpenoid alkaloids. It is a natural product derived from the rauwolfia plant and has been studied for its potential pharmacological properties, including antitumor and cytotoxic activities. (13S)-14-Deethylidene-13-hydroxy-17-norcrotalanan-11,15-dione's chemical structure features various functional groups, such as hydroxyl and ketone groups, which contribute to its biological activity.
Used in Pharmaceutical Industry:
(13S)-14-Deethylidene-13-hydroxy-17-norcrotalanan-11,15-dione is used as a pharmaceutical candidate for its potential antitumor and cytotoxic properties. Its unique chemical structure and functional groups contribute to its biological activity, making it a promising compound for further research and development in the field of oncology.
Used in Research and Development:
(13S)-14-Deethylidene-13-hydroxy-17-norcrotalanan-11,15-dione is used as a subject of research and development to better understand its pharmacological properties and potential applications. Further studies are needed to explore its full potential and effects, as well as to develop novel drug delivery systems or therapeutic approaches that can enhance its efficacy and bioavailability.
Check Digit Verification of cas no
The CAS Registry Mumber 480-87-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 480-87:
(5*4)+(4*8)+(3*0)+(2*8)+(1*7)=75
75 % 10 = 5
So 480-87-5 is a valid CAS Registry Number.
480-87-5Relevant articles and documents
Synthesis and Stereochemistry of Dicrotaline, a Macrocyclic Pyrrolizidine Alkaloid
Devlin, J. Alastair,Robins, David J.
, p. 1272 - 1274 (1981)
Dicrotaline (3) and its C-13 epimer (4) have been synthesized and the absolute configuration at C-13 of both alkaloids has been established by specific degradation of each epimer to optically active mevalonolactone.
Macrocyclic Pyrrolizidine Alkaloids. Synthesis and Stereochemistry of (+)-Dicrotaline (13β-Hydroxy-13α-methyl-1,2-didehydrocrotalanine) and (+)-13-epi-Dicrotaline
Brown, Kenneth,Devlin, J. Alastair,Robins, David J.
, p. 1819 - 1824 (2007/10/02)
Treatment of (+)-retronecine (1) with the trimethylsilyl ether of 3-hydroxy-3-methylglutaric anhydride gave a mixture of the 7- and 9-monoesters of (+)-retronecine (1).Lactonisation of this mixture was achieved using the corresponding pyridine-2-thiol esters to give (+)-dicrotaline (13β-hydroxy-13α-methyl-1,2-didehydrocrotalanine) (2) and (+)-13-epi-dicrotaline (3).The absolute configuration at C-13 in both compounds was established by a sequence of selective reactions on each epimer to yield optically active mevalonolactone.
