480424-47-3

Basic information

• Product Name: Zinc, chloro[(4-cyanophenyl)methyl]-
• CAS NO: 480424-47-3
• Molecular Formula: C8H6ClNZn
• Molecular Weight: 216.985
• Mol File: 480424-47-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Zinc, chloro[(4-cyanophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Zinc, chloro[(4-cyanophenyl)methyl]-(480424-47-3)
• EPA Substance Registry System: Zinc, chloro[(4-cyanophenyl)methyl]-(480424-47-3)

Safety Data

• Hazardous Substances Data: 480424-47-3(Hazardous Substances Data)

Upstream product

• 874-86-2 4-cyanobenzyl chloride 
• 7440-66-6 zinc 

Downstream Products

• 59475-60-4 4-[(p-tolylsulfonyl)methyl]benzonitrile 
• 1057679-00-1 6-{4-[4-(4-cyanobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile 

Relevant articles and documents

CuI catalyzed sulfonylation of organozinc reagents with sulfonyl halides

In this study, a facile CuI catalyzed synthesis of sulfones involving a nucleophilic addition of functionalized organozinc reagents to organic sulfonyl chlorides is realized. This reaction proceeds efficiently at room temperature, giving rise to various functional group substituted sulfones, generally in moderate to high yields. The method provides a novel, simple, and promising strategy for functionalized sulfone synthesis in the research field of sulfur chemistry. the Partner Organisations 2014.

NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.