480424-94-0

Basic information

• Product Name: N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE
• Synonyms: 4-FORMYLAMINOPHENYLBORONIC ACID, PINACOL ESTER;N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE;4-formamidophenylboronic acid pinacol ester;4-Formamidophenylboronic acid pinacol ester, N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]formamide
• CAS NO: 480424-94-0
• Molecular Formula: C13H18BNO3
• Molecular Weight: 247.1
• EINECS: 941-095-7
• Product Categories: Heterocyclic Compounds
• Mol File: 480424-94-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 116.7-118.2°C
• Boiling Point: 403.6 °C at 760 mmHg
• Flash Point: 197.9 °C
• Appearance: /
• Density: 1.09 g/cm³
• Vapor Pressure: 1E-06mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C
• PKA: 15.13±0.70(Predicted)
• CAS DataBase Reference: N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE(480424-94-0)
• EPA Substance Registry System: N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE(480424-94-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 480424-94-0(Hazardous Substances Data)

Usage

Uses

4-Formamidophenylboronic acid, pinacol ester

InChI:InChI=1/C13H18BNO3/c1-12(2)13(3,4)18-14(17-12)10-5-7-11(8-6-10)15-9-16/h5-9H,1-4H3,(H,15,16)

Upstream product

• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 109-94-4 formic acid ethyl ester 
• 64-18-6 formic acid 
• 141-53-7 sodium formate 

Relevant articles and documents

Chemoselective Schwartz Reagent Mediated Reduction of Isocyanates to Formamides

Addition of the in situ generated Schwartz reagent to widely available isocyanates constitutes a chemoselective, high-yielding, and versatile approach to the synthesis of variously functionalized formamides. Steric and electronic factors or the presence of sensitive functionalities (esters, nitro groups, nitriles, alkenes) do not compromise the potential of the method. Full preservation of the stereochemical information contained in the starting materials is observed. The use of formamides in the nucleophilic addition of organometallic reagents (Chida-Sato allylation, Charette-Huang addition to imidoyl triflate activated amides, Matteson homologation of boronic esters) is briefly investigated.

NOVEL BIPHENYL COMPOUNDS AND THEIR USE

The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereo