480453-85-8Relevant articles and documents
Synthesis and biological activity of imidazopyridine anticoccidial agents: Part I
Scribner, Andrew,Dennis, Richard,Hong, Jean,Lee, Shuliang,McIntyre, Donald,Perrey, David,Feng, Dennis,Fisher, Michael,Wyvratt, Matthew,Leavitt, Penny,Liberator, Paul,Gurnett, Anne,Brown, Chris,Mathew, John,Thompson, Donald,Schmatz, Dennis,Biftu, Tesfaye
, p. 1334 - 1357 (2008/09/17)
Coccidiosis is the major cause of morbidity and mortality in the poultry industry. Protozoan parasites of the genus Eimeria invade the intestinal lining of the avian host causing tissue pathology, poor weight gain, and in some cases mortality. Resistance
Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents
Biftu, Tesfaye,Feng, Dennis,Fisher, Michael,Liang, Gui-Bai,Qian, Xiaoxia,Scribner, Andrew,Dennis, Richard,Lee, Shuliang,Liberator, Paul A.,Brown, Chris,Gurnett, Anne,Leavitt, Penny S.,Thompson, Donald,Mathew, John,Misura, Andrew,Samaras, Samantha,Tamas, Tamas,Sina, Joseph F.,McNulty, Kathleen A.,McKnight, Crystal G.,Schmatz, Dennis M.,Wyvratt, Matthew
, p. 2479 - 2483 (2007/10/03)
Compounds 10a (IC50 110 pM) and 21 (IC50 40 pM) are the most potent inhibitors of Eimeria tenella cGMP-dependent protein kinase activity reported to date and are efficacious in the in vivo antiparasitic assay when administered to chi