481-97-0 Usage
Description
PREMARIN, also known as Estrone Sulfate, is a steroid sulfate that serves as a precursor to estrogen. It is a circulating steroid found in men, non-pregnant women, and post-menopausal women. PREMARIN plays a crucial role in the hormonal balance and overall health of individuals.
Uses
Used in Pharmaceutical Industry:
PREMARIN is used as a hormone replacement therapy for post-menopausal women. It helps alleviate symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness. Additionally, it can be used to prevent osteoporosis and reduce the risk of heart disease in post-menopausal women.
Used in Hormone Regulation:
PREMARIN is used as a hormone regulator in both men and non-pregnant women. It helps maintain hormonal balance and supports overall health by providing the necessary precursor to estrogen.
Used in Research and Development:
As a precursor to estrogen, PREMARIN is also used in research and development for the study of hormonal effects and the development of new medications related to hormone regulation and treatment of hormone-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 481-97-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 1 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 481-97:
(5*4)+(4*8)+(3*1)+(2*9)+(1*7)=80
80 % 10 = 0
So 481-97-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,18+/m1/s1
481-97-0Relevant articles and documents
Piperazine estrone sulfate preparation method
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Paragraph 0027-0029; 0033-0035; 0039-0041, (2020/01/03)
The invention relates to a high-purity estra-1,3,5(10)-triene-17-one-3-piperazine sulfate (1:1) (i.e., piperazine estrone sulfate) preparation method, which has characteristics of mild reaction conditions, simple post-treatment operation and easy impurity control, so that the quality of the prepared piperazine estrone sulfate is controllable, and the stability is high. The preparation method comprises the following main steps: 1) dissolving estrone in an organic solvent, and carrying a reaction with a sulfonating reagent to obtain estra-1,3,5(10)-triene-17-one-3-sulfate; and 2) dissolving piperazine in an organic solvent, then adding into the organic solution of the estra-1,3,5(10)-triene-17-one-3-sulfate, separating out a solid, filtering, washing, and drying to obtain the high-purity piperazine estrone sulfate product.
Production, clearence rates and metabolic fate of estradiol-17β in the plasma of the laying hen
Tsang,Grunder
, p. 71 - 84 (2007/10/02)
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Steroid conjugates IV. The preparation of steroid sulfates with triethylamine-sulfur trioxide.
Dusza,Joseph,Bernstein
, p. 49 - 61 (2007/11/07)
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