481052-60-2Relevant articles and documents
METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES
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, (2015/12/08)
Methods and compositions are provided for generating macrocyclic peptides from genetically encoded, ribosomally produced polypeptide precursors. Also provided are nucleic acid molecules, polypeptides, and methods for generating combinatorial libraries of
Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization
Hamamoto, Toshimasa,Sisido, Masahiko,Ohtsuki, Takashi,Taki, Masumi
, p. 9116 - 9118 (2011/10/04)
By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.