481075-38-1

Basic information

• Product Name: 2-FLUORO-5-HYDROXYMETHYL-BENZOIC ACID
• Synonyms: 2-FLUORO-5-HYDROXYMETHYL-BENZOIC ACID;RARECHEM AL BO 2247;Benzoic acid, 2-fluoro-5-(hydroxymethyl)-
• CAS NO: 481075-38-1
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• Product Categories: pharmacetical
• Mol File: 481075-38-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 353.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.417±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.27±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-5-HYDROXYMETHYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-HYDROXYMETHYL-BENZOIC ACID(481075-38-1)
• EPA Substance Registry System: 2-FLUORO-5-HYDROXYMETHYL-BENZOIC ACID(481075-38-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 481075-38-1(Hazardous Substances Data)

Usage

General Description

2-Fluoro-5-hydroxymethyl-benzoic acid is a chemical compound with the molecular formula C8H7FO3. It is a derivative of benzoic acid and contains a fluorine atom and a hydroxymethyl group. 2-FLUORO-5-HYDROXYMETHYL-BENZOIC ACID is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. It is also utilized as a building block in organic synthesis for the creation of various complex molecules. Additionally, 2-fluoro-5-hydroxymethyl-benzoic acid has potential applications in the development of new materials and in academic research.

Upstream product

• 709-45-5 2-fluoro-5-bromomethyl benzoic acid methyl ester 
• 124-38-9 carbon dioxide 
• 104620-55-5 1-fluoro-4-[(methoxymethoxy)methyl]benzene 
• 459-56-3 4-fluorobenzylic alcohol 
• 227609-85-0 2-fluoro-5-(hydroxymethyl)benzonitrile 

Downstream Products

• 816449-70-4 methyl 2-fluoro-5-(hydroxymethyl)benzoate 
• 891833-15-1 4-(2-Fluoro-5-hydroxymethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.

TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. More precisely, the present invention relates to tricyclic derivatives as colchicine derivatives, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. Tricyclic derivatives of the present invention show very powerful cytotoxicity to cancer cell lines but were much less toxic than colchicine or taxol, confirmed through animal toxicity test. Tricyclic derivatives of the invention also decrease the volume and weight of a tumor and have a strong angiogenesis inhibiting activity in HUVEC cells. Thus, tricyclic derivatives of the present invention can effectively be used as an anticancer agent, anti-proliferation agent and an angiogenesis inhibitor.