481075-59-6

Basic information

• Product Name: 1-BROMO-3-IODO-5-TRIFLUOROMETHYL-BENZENE
• Synonyms: 1-BROMO-3-IODO-5-TRIFLUOROMETHYL-BENZENE;1-Bromo-3-iodo-5-(trifluoromethyl)benzene, 3-Bromo-5-iodo-alpha,alpha,alpha-trifluorotoluene;3-Bromo-5-Iodo-alpha,alpha,alpha-Trifluorotoluene
• CAS NO: 481075-59-6
• Molecular Formula: C₇H₃BrF₃I
• Molecular Weight: 350.9023996
• Mol File: 481075-59-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 237.5±40.0 °C(Predicted)
• Appearance: /
• Density: 2.176±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-BROMO-3-IODO-5-TRIFLUOROMETHYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-3-IODO-5-TRIFLUOROMETHYL-BENZENE(481075-59-6)
• EPA Substance Registry System: 1-BROMO-3-IODO-5-TRIFLUOROMETHYL-BENZENE(481075-59-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 481075-59-6(Hazardous Substances Data)

Usage

General Description

1-Bromo-3-iodo-5-trifluoromethyl-benzene is a chemical compound with the molecular formula C7H3BrF3I. It is a halogenated benzene derivative, containing bromine, iodine, and trifluoromethyl groups attached to the benzene ring. 1-BROMO-3-IODO-5-TRIFLUOROMETHYL-BENZENE is widely used in organic synthesis as a building block for a variety of pharmaceuticals, agrochemicals, and materials. Its unique structure and properties make it suitable for use in the development of new chemical compounds and materials. It is also used as an intermediate in the manufacturing of various fine chemicals, and has applications in the fields of medicine, agriculture, and materials science.

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 481075-58-5 2-bromo-1-iodo-4-(trifluoromethyl)benzene 

Downstream Products

• 328-67-6 3-bromo-5-(trifluoromethyl)benzoic acid 
• 1215077-33-0 C₁₄H₈BrF₃OS 

Relevant articles and documents

Fluoro- or trifluoromethyl-substituted benzyl and phenethyl alcohols: Substrates for metal-mediated site-selective functionalization

It was possible to functionalize the three fluorobenzyl alcohols and the three 2-(fluorophenyl)ethanols by metalation and subsequent carboxylation, the prototype electrophilic trapping reaction. Triisopropylsilyl (TIPS) outperformed methoxymethyl (MOM) as an O-protective group making seven new fluorobenzoic acids accessible in 63% average yield. Moreover, the TIPS group tolerates weakly basic and acidic media and, therefore, may facilitate further structural elaboration. The unprotected alcohols reacted more sluggishly and were unable to provide two of the targeted products (acids 1 and 2). The yield averaged only 46% in the five other cases (acids 3-7). The direct metalation of fluorinated benzyl and phenethyl alcohols remains nevertheless an attractive option because of its operational simplicity. All three (trifluoromethyl)benzyl alcohols and two of the three (trifluoromethyl)phenethyl alcohol isomers were successfully submitted to the metalation/functionalization sequence. These five starting materials gave rise to a total of nine new benzoic acids or lactones (compounds 8-14 and 17-18). Despite the poor yields (31% on average), the organometallic methods employed are, in general, extremely selective, economical and easy to perform. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.