4812-40-2 Usage
Description
1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole is a compound belonging to the imidazole class, characterized by the presence of a nitro group and hydroxyethyl and hydroxymethyl functional groups. It is an off-white solid with potential applications in various fields due to its chemical properties.
Uses
Used in Pharmaceutical Research:
1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole is used as a research compound for the development of new drugs targeting bacterial and protozoal infections. Its chemical structure, derived from the nitroimidazole class, suggests potential antimicrobial and antiprotozoal activities, making it a valuable candidate for further investigation.
Used in Agricultural Production:
In the agricultural industry, 1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole can be used as a veterinary drug to expel parasites in animals. Its effectiveness in treating certain infections in poultry and swine, as well as genital trichomoniasis in cattle, highlights its potential as a valuable addition to the veterinary medicine arsenal.
Used in Toxicology and Safety Assessment:
Due to the potential toxic and side effects of metronidazole, a related compound, on human health, including carcinogenicity and hereditary mutation effects, 1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole can be used in the inspection and assessment of residual metronidazole and its metabolites in eggs. This application aids in ensuring the safety of the food supply and protecting public health.
Used in Material Science:
The chemical properties of 1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole, such as its solid-state structure and functional groups, may also find applications in material science. It could potentially be utilized in the development of new materials with specific properties, such as those with antimicrobial or antifungal capabilities, for use in various industries.
Biological Activity
Hydroxymetronidazole is an active metabolite of the antibiotic metronidazole (Item No. 9002409). It is formed from metronidazole primarily by the cytochrome P450 (CYP) isoform CYP2A6. Hydroxymetronidazole is active against B. fragilis, B. thetaiotaomicron, B. distasonis, and B. ovatus (MICs = 1, 2, 1, and 2 μg/ml, respectively). It has been found in pork and porcine plasma.
Check Digit Verification of cas no
The CAS Registry Mumber 4812-40-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,1 and 2 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4812-40:
(6*4)+(5*8)+(4*1)+(3*2)+(2*4)+(1*0)=82
82 % 10 = 2
So 4812-40-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H9N3O4/c10-2-1-8-5(4-11)7-3-6(8)9(12)13/h3,10-11H,1-2,4H2
4812-40-2Relevant articles and documents
A comparative study of precision cut liver slices, hepatocytes, and liver microsomes from the Wistar rat using metronidazole as a model substance
Sidelmann,Cornett,Tjornelund,Hansen
, p. 709 - 722 (2007/10/03)
1. Metronidazole is metabolized by rat liver in vitro models to form a hydroxy metabolite, an acetic acid metabolite, a glucuronic acid conjugate, and a sulphate conjugate; 2. Four different in vitro systems for investigation of drug metabolism based on liver preparations from the male Wistar rat have been investigated. 3. An incubation system where liver slices are Incubated in 12-well culture plates was evaluated with respect to metabolism of metronidazole. Optimal viability was observed for a time period of up to 24 h. The Michaelis-Menten parameters for the metabolism of metronidazole in liver slices were calculated and the intrinsic clearance values compared with the values determined in hepatocytes incubated in suspension,It was found that the intrinsic clearance with respect to formation of oxidative metabolites, the hydroxy metabolite, and the acetic acid metabolite correlated, whereas the intrinsic clearance with respect to formation of the glucuronic acid conjugate was lower in slices compared with hepatocytes. 4. The metabolism of metronidazole in liver slices, in hepatocytes in primary monolayer culture, in hepatocytes incubated in suspension, and in liver microsomes was compared. All the incubations were performed under identical incubation conditions including the same incubation medium. The trend observed was that the initial metabolic rates of the production of the hydroxy metabolite, the glucuronic acid metabolite, and the acetic acid metabolite of metronidazole were higher in microsomes than in the other liver preparations. The metabolic rates in hepatocytes in primary culture and in suspension with respect to the oxidative metabolites were higher than in liver slices. The metabolic turnover observed in liver slices was predicted to correlate with in vivo data earlier obtained for rat.
