4815-97-8

Basic information

• Product Name: 2-bromo-3,4-dihydroxybenzaldehyde
• Synonyms: 2-bromo-3,4-dihydroxybenzaldehyde
• CAS NO: 4815-97-8
• Molecular Weight: 217.019
• Mol File: 4815-97-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-bromo-3,4-dihydroxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-3,4-dihydroxybenzaldehyde(4815-97-8)
• EPA Substance Registry System: 2-bromo-3,4-dihydroxybenzaldehyde(4815-97-8)

Safety Data

• Hazardous Substances Data: 4815-97-8(Hazardous Substances Data)

Upstream product

• 55171-60-3 2-bromo-3,4-dimethoxybenzylaldehyde 
• 621-59-0 isovanillin 
• 2973-58-2 2-bromoisovanillin 

Downstream Products

• 164991-68-8 decumbenine B 
• 1372864-96-4 5-(2-bromo-3,4-dihydroxybenzylidene)-3-(2-ethylbutyl)thiazolidine-2,4-dione 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 4815-98-9 O,O-Dibenzyl-2-brom-protocatechualdehyd 
• 1075694-36-8 (3,4-bis(methoxymethoxy)-2-(3-methylbut-2-en-1-yl)phenyl)methanol 

Relevant articles and documents

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Novel method for preparing decumbenine B

The invention provides a novel method for preparing a natural compound decumbenine B. The method comprises the following steps: (i) enabling a compound shown as a formula 4 and a compound shown as a formula 5 to be in contact under a condition suitable for carbon-carbon coupling, so as to generate a compound shown as a formula 3; (ii) carrying out cyclization on the compound shown as the formula 3and ammonium acetate under a suitable condition, so as to generate a compound 2; (iii) enabling the compound shown as the formula 2 and paraformaldehyde to react under the suitable condition, so as to generate the compound decumbenine B shown as a formula 1. (The formula 5, the formula 4, the formula 3, the formula 2 and the formula 1 are shown in the description.).

Short synthesis of noscapine, bicuculline, egenine, capnoidine, and corytensine alkaloids through the addition of 1-siloxy-isobenzofurans to imines

A concise diastereotioselective strategy for the synthesis of noscapine, bicuculline, and egenine (1a-c), as well as capnoidine and corytensine (2a,b), was developed using diastereoselective addition of 1-siloxy-isobenzofurans 4a and 4b to iminium ion 5 in a one-pot approach. The synthesis features the use of imine 13 obtained through Bischler-Napieralsky reaction from amine 11. The addition of ionic liquids as addictives in the reactions afforded erythro configuration in major adduct compounds. The synthetic route can also be applied in the total synthesis of promising tubulin binding agent EM105 (3).