48180-65-0

Basic information

• Product Name: 4,4'-DIAZIDODIPHENYL ETHER
• Synonyms: DADE;4,4'-DIAZIDODIPHENYL ETHER;DADE (4-4'-Diazidodiphenyl ether)
• CAS NO: 48180-65-0
• Molecular Formula: C₁₂H₈N₆O
• Molecular Weight: 252.23
• Product Categories: photoazide
• Mol File: 48180-65-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,4'-DIAZIDODIPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-DIAZIDODIPHENYL ETHER(48180-65-0)
• EPA Substance Registry System: 4,4'-DIAZIDODIPHENYL ETHER(48180-65-0)

Safety Data

• Hazardous Substances Data: 48180-65-0(Hazardous Substances Data)

Usage

General Description

4,4'-Diazidodiphenyl ether, also known as DAPE, is a white or light yellow crystalline solid often used as a chemical intermediate in the production of polymers and resins. It is primarily utilized as a cross-linking agent in the formulation of high-performance materials with enhanced mechanical and thermal properties, such as adhesives, coatings, and composites. 4,4'-DIAZIDODIPHENYL ETHER is highly reactive, releasing nitrogen gas when exposed to ultraviolet or thermal energy, making it suitable for photolithography and other photochemical processes. Furthermore, 4,4'-diazidodiphenyl ether is commonly employed in the manufacturing of printed circuit boards, protective coatings, and photoresists due to its excellent photostability and resistance to chemical degradation. However, it is important to handle this compound with caution as it is potentially harmful if ingested, inhaled, or absorbed through the skin, and it may cause irritation or allergic reactions upon contact.

Upstream product

• 101-63-3 bis(4-nitrophenyl)ether 
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• 101-80-4 4,4'-oxydiphenylene diamine 

Relevant articles and documents

1,3-dipolar cycloaddition: Free catalytic synthesis and esophageal cancer activity of new 1,2,3-triazole-oxydianiline-maleimide hybrids

A new series of 1,2,3-triazole-oxydianiline-maleimide hybrids 12-15 was synthesized by using 1,3-dipolar cycloaddition reaction of N-Arylmaleimides 6-9 with 4,4'-oxybis(azidobenzene) 11 under an efficient and free catalytic reaction. All the newly synthesized hybrids were characterized by their 1H NMR, F-TIR, Mass spectral data and melting points. The cytotoxic activities (in vitro) of selected hybrids against esophageal cancer of human cell line (SKG) were evaluated by MTT assay. Among them, hybrid 13 exhibited a potent inhibition activity with the IC50 value of 1.61±0.01 μM against esophageal cancer cell (SKG). Cellular mechanism investigations in esophageal carcinoma cells (SKG) elucidated that hybrid 13 inhibited cell growths in vitro and arrested cell cycle at an environmental phase. These results revealed that hybrid 13 holds a promising anticancer agent with the enhancement of further clinical applications in drug discovery field.

Metal- and Phenol-Free Synthesis of Biaryl Ethers: Access to Dibenzobistriazolo-1,4,7-oxadiazonines and Vancomycin-Like Glyco-Macrocycles as Antibacterial Agents

An efficient synthesis of biaryl ethers, from electron-deficient aryl halides using NaH/DMSO under metal- and phenol-free conditions, has been achieved to access dibenzo-bistriazolo-1,4,7-oxadiazonines and vancomycin-like glyco-macrocycles. A 44-membered glyco-macrocycle showed promising activity against vancomycin-resistant Staphylococcus aureus (VRSA).

Size-specific ligands for RNA hairpin loops

The targeting of one mRNA in the transcriptome requires small molecules that bind with substantial affinity and specificity. As such, compounds with specificity for individual RNA secondary structural motifs could be useful for targeting RNA. Described herein is the synthesis of a combinatorial library of 105 dimers of deoxystreptamine and the subsequent identification of compounds with specificity for specific RNA hairpin loop sizes, including tetraloops and octaloops. Such compounds will be useful for the perturbation of RNA function in vivo. Copyright