4819-77-6 Usage
Description
1,1,2-Triethoxyethane, also known as 2-(2-ethoxyethoxy)ethanol, is an organic compound that serves as a versatile intermediate in the synthesis of various pharmaceutical compounds. It is a colorless liquid with a mild odor and is characterized by its three ethoxy groups attached to a central ethane molecule.
Uses
1,1,2-Triethoxyethane is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, including COX-2 selective inhibitors and antiviral agents.
Used in Pharmaceutical Industry:
1,1,2-Triethoxyethane is used as an intermediate for the synthesis of pyrazolopyrimidine derivatives, which act as COX-2 selective inhibitors. These inhibitors are important in the development of anti-inflammatory and pain-relieving medications, as they help reduce inflammation and pain by selectively targeting the COX-2 enzyme.
1,1,2-Triethoxyethane is also used as an intermediate in the preparation of [(1,2,4-oxadiazolylphenoxy)alkyl]isoxazoles, which are antiviral agents. These compounds have potential applications in the development of treatments for various viral infections, including influenza and other respiratory illnesses.
Purification Methods
Dry it with Na2SO4, and distil it. [McElvain & Walters J Am Chem Soc 64 1964 1942, Beilstein 1 H 818, 1 I 418, 1 III 3184, 1 IV 3958.]
Check Digit Verification of cas no
The CAS Registry Mumber 4819-77-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,1 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4819-77:
(6*4)+(5*8)+(4*1)+(3*9)+(2*7)+(1*7)=116
116 % 10 = 6
So 4819-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H18O3/c1-4-9-7-8(10-5-2)11-6-3/h8H,4-7H2,1-3H3
4819-77-6Relevant articles and documents
ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS
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Page/Page column 73-74, (2011/06/19)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Umsatz und kinetische Modellierung der Bildung von Formaldehyd, Ethylenglycol und Ameisensaeure bei der oxidativen Alkohol-Thermolyse
Spangenberg, H.-J.,Lachmann, J.,Boerger, I.,Dessau, L.,Fiebig, W.,Levitzky, A. A.
, p. 5 - 16 (2007/10/02)
In this paper the investigation about oxy-thermolysis of simple organic compounds is extended to the formation of aldehyds, ethylene glycol, formic acid and others received from methanol and ethanol in the occurence of oxygen in the temperature range 900 K T 1100 K.Probable intermediate radicalic species are CH3O and CH2OH, kinetically treated as one kind of molecules.An improved system of reaction rate equations is solved.The calculated concentrations depending on time reach a maximum near 0.3 s and are compared with measured chemical concentrations.Finally it is given a sensitivity analysis of the reaction rate system.
