482-45-1 Usage
Description
Isoimperatorin is a member of the psoralen class, characterized by a psoralen molecule substituted by a prenyloxy group at position 5. It is primarily isolated from Angelica dahurica and Angelica koreana plants and exhibits properties of an acetylcholinesterase inhibitor. Isoimperatorin is a white solid with various applications in different industries due to its unique chemical properties and biological activities.
Uses
Used in Pharmaceutical Industry:
Isoimperatorin is used as an anti-inflammatory agent for its ability to modulate the inflammatory response and alleviate associated symptoms. It is also utilized for its effect on cell proliferation, which can be beneficial in the treatment of certain conditions.
Used in Neurological Applications:
Isoimperatorin is used as an acetylcholinesterase inhibitor for its potential neurological benefits. By inhibiting the enzyme acetylcholinesterase, it can help maintain higher levels of the neurotransmitter acetylcholine, which is essential for cognitive functions and memory.
Used in Cosmetic Industry:
Isoimperatorin is used as an active ingredient in the cosmetic industry for its anti-inflammatory and cell proliferation effects. These properties can contribute to the development of skincare products that address inflammation, promote skin healing, and improve overall skin health.
Used in Research and Development:
Isoimperatorin is used as a research compound for its unique chemical structure and biological activities. It serves as a valuable tool in the study of various biological processes and the development of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 482-45-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 2 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 482-45:
(5*4)+(4*8)+(3*2)+(2*4)+(1*5)=71
71 % 10 = 1
So 482-45-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H14O4/c1-10(2)5-7-19-16-11-3-4-15(17)20-14(11)9-13-12(16)6-8-18-13/h3-6,8-9H,7H2,1-2H3
482-45-1Relevant articles and documents
Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants
Munakata, Ryosuke,Olry, Alexandre,Takemura, Tomoya,Tatsumi, Kanade,Ichino, Takuji,Villard, Cloé,Kageyama, Joji,Kurata, Tetsuya,Nakayasu, Masaru,Jacob, Florence,Koeduka, Takao,Yamamoto, Hirobumi,Moriyoshi, Eiko,Matsukawa, Tetsuya,Grosjean, Jérémy,Krieger, Célia,Sugiyama, Akifumi,Mizutani, Masaharu,Bourgaud, Frédéric,Hehn, Alain,Yazaki, Kazufumi
, (2021/05/11)
Plants produce ～300 aromatic compounds enzymatically linked to prenyl side chains via C–O bonds. These O-prenylated aromatic compounds have been found in taxonomically distant plant taxa, with some of them being beneficial or detrimental to human health. Although their O-prenyl moieties often play crucial roles in the biological activities of these compounds, no plant gene encoding an aromatic O-prenyltransferase (O-PT) has been isolated to date. This study describes the isolation of an aromatic O-PT gene, CpPT1, belonging to the UbiA superfamily, from grapefruit (Citrus × paradisi, Rutaceae). This gene was shown responsible for the biosynthesis of O-prenylated coumarin derivatives that alter drug pharmacokinetics in the human body. Another coumarin O-PT gene encoding a protein of the same family was identified in Angelica keiskei, an apiaceous medicinal plant containing pharmaceutically active O-prenylated coumarins. Phylogenetic analysis of these O-PTs suggested that aromatic O-prenylation activity evolved independently from the same ancestral gene in these distant plant taxa. These findings shed light on understanding the evolution of plant secondary (specialized) metabolites via the UbiA superfamily.
Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4
Row,Brown,Stachulski,Lennard
, p. 1604 - 1610 (2008/02/03)
A number of furanocoumarins isolated from grapefruit juice have been found to inhibit CYP3A4 activity in vitro. In this study, we have designed and synthesised a range of analogues based on bergamottin to investigate the relationship between chemical stru
