482-85-9 Usage
Description
(-)-ISORESERPINE is a chemical compound that is an alkaloid derived from the Rauwolfia plant. It is a stereoisomer of reserpine and possesses similar pharmacological effects, including acting as a dopamine receptor antagonist and a serotonin receptor antagonist. (-)-ISORESERPINE is known for its ability to reduce blood pressure by inhibiting the sympathetic nervous system, as well as its potential antipsychotic and sedative properties, making it a valuable asset in the treatment of certain mental health disorders.
Uses
Used in Pharmaceutical Industry:
(-)-ISORESERPINE is used as an antihypertensive agent for its ability to reduce blood pressure by inhibiting the sympathetic nervous system. This makes it a crucial component in the management and treatment of hypertension and related cardiovascular conditions.
Used in Mental Health Treatment:
(-)-ISORESERPINE is used as an antipsychotic and sedative agent due to its potential to alleviate symptoms associated with certain mental health disorders. Its dopamine and serotonin receptor antagonist properties contribute to its effectiveness in managing conditions such as schizophrenia, bipolar disorder, and depression.
Used in Research and Development:
(-)-ISORESERPINE serves as a valuable compound in scientific research and development, particularly in the fields of neuroscience and pharmacology. Its unique properties as a dopamine and serotonin receptor antagonist make it an important tool for studying the mechanisms of action and potential therapeutic applications in various neurological and psychiatric conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 482-85-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 482-85:
(5*4)+(4*8)+(3*2)+(2*8)+(1*5)=79
79 % 10 = 9
So 482-85-9 is a valid CAS Registry Number.
482-85-9Relevant articles and documents
A Desymmetrization-Based Total Synthesis of Reserpine
Park, Jisook,Chen, David Y.-K.
, p. 16152 - 16156 (2018/11/23)
Reported herein is a desymmetrization-based synthetic approach to the fused polycyclic indole alkaloid reserpine. The centerpiece of the developed strategy features an internal desymmetrization process that enabled the use of a readily accessible and nonstereogenic reserpine E-ring precursor, in contrast to the synthesis-intensive and stereodefined E-ring intermediates employed in all past reserpine syntheses. Utilization of inexpensive reagents through an orchestrated sequence of carefully selected chemical transformations further highlight the overall effectiveness of the developed pathway.
Novel zinc mediated indole ring opening of isoreserpine
Berner, Mathias,Tolvanen, Arto,Lounasmaa, Mauri,Jokela, Reija
, p. 2941 - 2948 (2007/10/03)
Reaction of reserpine'(1) with Zn/TFA resulted in isoreserpine (2), dihydro compound (7), and amino compound (8) via initial epimerization at C- 3. The latter two compounds constitute a novelty in indole alkaloid chemistry: the dihydro compound (7) posses
Genaral Strategies for the Synthesis of Indole Alkaloids. Total Syntheses of (+/-)-Reserpine and (+/-)-α-Yohimbine
Martin, Stephen F.,Rueeger, Heinrich,Williamson, Sidney A.,Grzejszczak, Slawomir
, p. 6124 - 6134 (2007/10/02)
The concise, total syntheses of the indole alkaloids (+/-)-reserpine (1) and (+/-)-α-yohimbine (4) have been completed by the application of a general strategy that features an intramolecular Diels-Alder reaction for the facile construction of the functio
