482649-59-2

Basic information

• Product Name: methyl 2-(but-2-yn-1-yl)-2-phenylhex-4-ynoate
• Synonyms: methyl 2-(but-2-yn-1-yl)-2-phenylhex-4-ynoate
• CAS NO: 482649-59-2
• Molecular Weight: 254.329
• Mol File: 482649-59-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2-(but-2-yn-1-yl)-2-phenylhex-4-ynoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(but-2-yn-1-yl)-2-phenylhex-4-ynoate(482649-59-2)
• EPA Substance Registry System: methyl 2-(but-2-yn-1-yl)-2-phenylhex-4-ynoate(482649-59-2)

Safety Data

• Hazardous Substances Data: 482649-59-2(Hazardous Substances Data)

Upstream product

• 56563-37-2 toluene-4-sulfonic acid but-2-ynyl ester 
• 101-41-7 benzeneacetic acid methyl ester 
• 3355-28-0 1-Bromo-2-butyne 

Downstream Products

• 1451053-47-6 (Z)-3-(but-2-ynyl)-5-ethylidene-3-phenyldihydrofuran-2(3H)-one 
• 1436872-11-5 C₁₆H₁₉BrO₂ 
• 1436872-00-2 (R,E)-5-(1-bromoethylidene)-3-(but-2-ynyl)-3-phenyldihydrofuran-2(3H)-one 
• 1436871-88-3 2-(but-2-yn-1-yl)-2-phenylhex-4-ynoic acid 
• 1381967-82-3 methyl 1,3,4-trimethyl-6-phenyl-6,7-dihydro-5H-cyclopenta[c]pyridine-6-carboxylate 
• 1352800-50-0 methyl 2-(n-butyl)-1,4-dimethyl-3-oxo-6-phenyl-5H-2,3,6,7-tetrahydrocyclopenta[c]pyridine-6-carboxylate 

Relevant articles and documents

Desymmetrization construction of chiral lactones by synergistic Cu(II) complex and organic base

A highly enantioselective construction of quaternary carbon center has been realized by the desymmetrization strategy. Chiral enol lactones with up to 95% ee could be synthesized from prochiral dialkynoic acid under the catalysis of synergistic chiral Cu(II) complex and chiral (DHQ)2-PHAL base.

Enantioselective, desymmetrizing bromolactonization of alkynes

Asymmetric bromolactonizations of alkynes are possible using a desymmetrization approach. The commercially available catalyst (DHQD) 2PHAL promotes these cyclizations in combination with cheap NBS as a bromine source to give bromoenol lactones in high yield and with high enantioselectivity. The bromoenol lactone products, containing a tetrasubstituted alkene and a quaternary stereocenter, are valuable building blocks for synthetic chemistry.