483-09-0 Usage
Description
(3β,20α)-17α-Hydroxyyohimban-16β-carboxylic acid methyl ester is a complex organic compound derived from the plant Rauvolfia serpentina. It is characterized by its unique molecular structure, which includes a hydroxyl group at the 17α position, a carboxylic acid group at the 16β position, and a methyl ester group. This molecule has potential applications in various fields due to its unique properties and interactions with biological systems.
Uses
Used in Pharmaceutical Industry:
(3β,20α)-17α-Hydroxyyohimban-16β-carboxylic acid methyl ester is used as a potential therapeutic agent for the treatment of diabetes and its complications. It functions as an inhibitor of aldose reductase, a key enzyme involved in the development of diabetic complications such as neuropathy, retinopathy, and cataracts. By inhibiting this enzyme, the compound can help prevent the accumulation of sorbitol and the subsequent cellular damage associated with diabetes.
Used in Drug Delivery Systems:
In the field of drug delivery, (3β,20α)-17α-Hydroxyyohimban-16β-carboxylic acid methyl ester can be utilized as a component in the development of novel drug delivery systems. Its unique molecular structure and functional groups may allow for the design of targeted drug carriers or enhance the bioavailability and efficacy of other therapeutic agents. Further research and development in this area could lead to innovative drug delivery solutions for various medical conditions.
Used in Chemical Research:
(3β,20α)-17α-Hydroxyyohimban-16β-carboxylic acid methyl ester can also be used as a starting material or intermediate in the synthesis of other complex organic compounds. Its unique structure and functional groups make it a valuable tool for researchers in the field of organic chemistry, where it can be used to explore new reactions, mechanisms, and applications in both academic and industrial settings.
Check Digit Verification of cas no
The CAS Registry Mumber 483-09-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 483-09:
(5*4)+(4*8)+(3*3)+(2*0)+(1*9)=70
70 % 10 = 0
So 483-09-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17-,18+,19+/m1/s1
483-09-0Relevant articles and documents
Total Syntheses of Yohimbe Alkaloids, with Stereoselection for the Normal, Allo, and 3-Epiallo Series, Based on Annelations of 4-Methoxy-1,2-dihydropyridones
Kuehne, Martin E.,Muth, Randy S.
, p. 2701 - 2712 (2007/10/02)
N--2,3-dihydro-4-pyridone (31) was generated in two steps (77percent yield) from tryptamine and N-methyl-4-piperidone methiodide.Its cyclization (90percent yield) and oxidation (91percent yield) provided the tetracyclic analogue 32.O-Methylation and Robinson-type annelation of these vinylogous lactams (the latter in form of its Na-carbamate) furnished the dienones 38 (64percent) and 43 (90percent).Further elaboration by cyclization and/or reduction reactions selectively provided the 15,16-didehydroyohimbinones 7 and 44.Their reductions then led to yohimbinone (52, 20percent overall yield from tryptamine), alloyohimbinone (11, 19percent overall yield), and 3-epi-alloyohimbinone (10, 23percent overall yield), which led to yohimbine (3), β-yohimbine (9), 3-epi-alloyohimbine (53), and 3-epi-17-epi-alloyohimbine (54).
Total synthesis of yohimbine.
van Tamelen,Shamma,Burgstahler,Wolinsky,Tamm,Aldrich
, p. 7315 - 7333 (2007/10/04)
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