4837-19-8

Basic information

• Product Name: 3-(DIFLUOROMETHOXY)BENZOIC ACID
• Synonyms: ART-CHEM-BB B009039;AKOS B009039;3-(DIFLUOROMETHOXY)BENZOIC ACID;RARECHEM AL BO 0845;3-(Difluoromethoxy)benzoic acid 98%;3-(Difluoromethoxy)benzoicacid98%;3-Carboxy-alpha,alpha-difluoroanisole
• CAS NO: 4837-19-8
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.13
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 4837-19-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 105°C
• Boiling Point: 287.3 °C at 760 mmHg
• Flash Point: 127.6 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.00116mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 3.89±0.10(Predicted)
• CAS DataBase Reference: 3-(DIFLUOROMETHOXY)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DIFLUOROMETHOXY)BENZOIC ACID(4837-19-8)
• EPA Substance Registry System: 3-(DIFLUOROMETHOXY)BENZOIC ACID(4837-19-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 4837-19-8(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

InChI:InChI=1/C8H6F2O3/c9-8(10)13-6-3-1-2-5(4-6)7(11)12/h1-4,8H,(H,11,12)/p-1

Upstream product

• 65-85-0 benzoic acid 
• 76903-91-8 3-(difluoromethoxy)benzoyl chloride 
• 108-39-4 3-methyl-phenol 
• 4837-15-4 1-(difluoromethoxy)-3-methylbenzene 

Relevant articles and documents

DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME

The present invention provides a compound having the structure (I), a processing of making the compound; and a process of using the compound as a reagent for the difluoromethoxylation and trifluoromethoxylation of arenes or heteroarenes.

Changes in the activity and selectivity of herbicides by selective fluorine substitution, taking bentranil and classic analogues as examples

The introduction of fluorine atoms into 2-phenyl-4H-3,1-benzoxazin-4-one (bentranil) led to sweeping changes in its herbicidal properties in some cases, and 5-fluoro-2-phenyl-4H-3,1-benzoxazin-4-one ('fluorobentranil') was found to be the most active compound. It can be prepared from 2-amino-6-fluoro-benzoic acid or by direct halogen exchange of 5-chloro-2-phenyl-4H-3,1-benzoxazin-4-one. The latter reaction was investigated on a pilot scale, including a high-temperature (350°C) potassium fluoride halogen exchange without solvent. When sulfolane was used as a solvent, a side reaction at 220°C - partial decomposition to a diphenylether - could be prevented by addition of a small amount of a radical scavenger. Other intermediates with a pseudohalogen substitution were obtained by side-chain chlorination of suitable methylsulfanyl benzoic acid precursors and halogen exchange. 'Fluorobentranil' shows good broad-leaf activity and selectivity on rice, cereals and maize. In a second case study, the fluoro-substituted anthranilic acids mentioned above were also found to be appropriate for synthesizing herbicidal sulfonylurea (SU) compounds via Meerwein reaction of their aniline function. Methyl 2-[({[(4-chloro-6-methoxy-2- pyrimidinyl)-amino]carbonyl}amino)sulfonyl]-6-fluorobenzoate is an example of a SU that is compatible with maize, whereas the unsubstituted Classic analogue is not selective.

4H-3,1-Benzoxazine derivatives

4H-3,1-Benzoxazine derivatives of the formula STR1 where R1, R2 and Y have the meanings given in the specification, and their use for controlling unwanted plant growth in numerous crops, such as cereals, Indian corn, soybeans and cot